EDA Complex-Mediated Aerobic Three-Component CDC Reactions of Quinoxalinones under Visible-Light Irradiation

IF 4.9 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-06-02 DOI:10.1021/acs.orglett.5c01704

Xiaoyuan Wan, Richang Wen, Yi Fang, Huawen Huang, Guo-Jun Deng

引用次数: 0

Abstract

A visible-light-induced Minisci-type three-component aerobic cross-dehydrogenative coupling (CDC) reaction of quinoxalinones with styrenes and acetophenones is described. The catalytic electron donor–acceptor (EDA) complexation of quinoxalinones with TMSCl is found to be the key for oxygen activation, which initiates the oxidative radical formation of acetophenones under photocatalyst-free conditions. This three-component protocol provides facile and efficient access to structurally valuable highly functionalized quinoxalinones with generally high chemoselectivity and moderate to good yields.

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可见光下EDA复合物介导喹啉酮类化合物需氧三组分CDC反应

报道了喹啉酮与苯乙烯和苯乙酮在可见光诱导下的微型三组分好氧交叉脱氢偶联反应。研究发现，在无光催化条件下，喹啉酮与TMSCl的电子给体-受体（EDA）催化络合是氧活化的关键，从而引发苯乙酮的氧化自由基形成。这种三组分方案提供了方便和有效的途径，结构上有价值的高功能化喹诺沙林酮具有普遍高的化学选择性和中等到良好的收率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.