Brain morphological changes in type 2 diabetes patients with painful peripheral neuropathy.

IF 3.5 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Miao He, Jiaying Yang, Xueqing Liu, Jiamin Zhou, Xuewei Zhang, Jing Li, Xiali Shao, Wenhui Li, Yuzhou Guan, Weihong Zhang, Feng Feng
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Abstract

We investigates changes in brain volume and cortical thickness in patients with type 2 diabetes mellitus (T2DM) and peripheral neuropathy (DPN), particularly those with neuropathic pain. 105 participants were divided into three groups: T2DM (n = 26), T2DM with DPN (n = 42), and healthy controls (HCs, n = 37). The DPN group was further divided into painless (n = 22) and painful (n = 20) subgroups. Participants underwent clinical neuropsychological testing, electromyography, and brain MRI scans. Voxel-based morphometry was used to analyze gray matter volume (GMV) and cortical thickness. Associations between morphological changes and clinical/neuropsychological indicators were assessed. Average cortical thickness of the three patient subgroups was significantly reduced compared to the HCs. GMV loss in the DPN_ pain group was confined to the cerebellum, right putamen/pallidum, and caudate, while GMV increased in the brainstem. Multiple regression analysis showed correlations between brain regions and factors such as cholesterol levels, neuropathic pain severity, and nerve amplitudes (P < 0.001). The volume of right lateral geniculate nucleus volume was linked to the DN4 score (r = 0.593, P = 0.015) and onset age (r = -0.541, P = 0.031). Specific brain regions and the cortices are more vulnerable to the effects of neuropathic pain and peripheral nerve damage.

伴有疼痛性周围神经病变的2型糖尿病患者的脑形态学改变。
我们研究了2型糖尿病(T2DM)和周围神经病变(DPN)患者,特别是神经性疼痛患者的脑容量和皮质厚度的变化。105名参与者被分为三组:T2DM (n = 26)、T2DM合并DPN (n = 42)和健康对照组(hc, n = 37)。DPN组又分为无痛组(n = 22)和疼痛组(n = 20)。参与者接受了临床神经心理测试、肌电图和脑部核磁共振扫描。基于体素的形态测量法分析脑灰质体积(GMV)和皮层厚度。评估形态学变化与临床/神经心理指标之间的关系。与hc相比,三个患者亚组的平均皮质厚度显著降低。DPN_疼痛组GMV下降仅限于小脑、右侧壳核/白质和尾状核,而脑干GMV升高。多元回归分析显示,脑区域与胆固醇水平、神经性疼痛严重程度和神经振幅等因素之间存在相关性
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来源期刊
Metabolic brain disease
Metabolic brain disease 医学-内分泌学与代谢
CiteScore
5.90
自引率
5.60%
发文量
248
审稿时长
6-12 weeks
期刊介绍: Metabolic Brain Disease serves as a forum for the publication of outstanding basic and clinical papers on all metabolic brain disease, including both human and animal studies. The journal publishes papers on the fundamental pathogenesis of these disorders and on related experimental and clinical techniques and methodologies. Metabolic Brain Disease is directed to physicians, neuroscientists, internists, psychiatrists, neurologists, pathologists, and others involved in the research and treatment of a broad range of metabolic brain disorders.
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