Melanoma innervation, noradrenaline and cancer progression in zebrafish xenograft model.

IF 6.1 2区生物学 Q1 CELL BIOLOGY

Cell Death Discovery Pub Date : 2025-05-31 DOI:10.1038/s41420-025-02523-8

Francesca Lorenzini, Johanna Marines, Julien Le Friec, Nam Do Khoa, Maria Angela Nieto, Berta Sanchez-Laorden, Maria Caterina Mione, Laura Fontenille, Karima Kissa

引用次数: 0

Abstract

The tumor microenvironment, including the peripheral nervous system, plays a key role in regulating tumor biology, from initiation to cancer progression. Here, by modeling aggressive melanoma in larval zebrafish xenografts, we shed light on the dynamics of tumor innervation in the tumor microenvironment (TME). Axonogenesis and dendritogenesis were detected in the neurons surrounding the melanoma niche and neurogenesis was observed in the nearby population of the enteric nervous system. We also demonstrate the crucial role of noradrenaline in promoting melanoma progression with the dissemination and invasion of cancer cells to distant tissues. This zebrafish model will allow to uncover neural markers associated with melanoma progression to help in the design of innovative anti-neurogenic therapies targeting specifically the neuronal signals that regulate melanoma progression.

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斑马鱼异种移植模型中黑色素瘤神经支配、去甲肾上腺素与肿瘤进展。

肿瘤微环境，包括周围神经系统，在调节肿瘤生物学中起着关键作用，从开始到癌症进展。在这里，通过模拟斑马鱼异种移植幼虫的侵袭性黑色素瘤，我们揭示了肿瘤微环境（TME）中肿瘤神经支配的动力学。在黑素瘤生态位周围的神经元中检测到轴突发生和树突发生，在肠道神经系统附近的人群中观察到神经发生。我们还证明了去甲肾上腺素在促进黑色素瘤的进展以及癌细胞向远处组织的传播和侵袭中的关键作用。这种斑马鱼模型将揭示与黑色素瘤进展相关的神经标志物，以帮助设计创新的抗神经源性疗法，特别是针对调节黑色素瘤进展的神经元信号。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell Death Discovery Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

8.30

自引率

1.40%

发文量

468

审稿时长

9 weeks

期刊介绍： Cell Death Discovery is a multidisciplinary, international, online-only, open access journal, dedicated to publishing research at the intersection of medicine with biochemistry, pharmacology, immunology, cell biology and cell death, provided it is scientifically sound. The unrestricted access to research findings in Cell Death Discovery will foster a dynamic and highly productive dialogue between basic scientists and clinicians, as well as researchers in industry with a focus on cancer, neurobiology and inflammation research. As an official journal of the Cell Death Differentiation Association (ADMC), Cell Death Discovery will build upon the success of Cell Death & Differentiation and Cell Death & Disease in publishing important peer-reviewed original research, timely reviews and editorial commentary. Cell Death Discovery is committed to increasing the reproducibility of research. To this end, in conjunction with its sister journals Cell Death & Differentiation and Cell Death & Disease, Cell Death Discovery provides a unique forum for scientists as well as clinicians and members of the pharmaceutical and biotechnical industry. It is committed to the rapid publication of high quality original papers that relate to these subjects, together with topical, usually solicited, reviews, editorial correspondence and occasional commentaries on controversial and scientifically informative issues.