Increased angiogenesis and lymphangiogenesis in rheumatic mitral valves

IF 2.3 4区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiovascular Pathology Pub Date : 2025-05-29 DOI:10.1016/j.carpath.2025.107744

Paavo Immonen , Pranita Zare , Ari Mennander , Timo Paavonen , Pradeep Vaideeswar , Ivana Kholová

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引用次数: 0

Abstract

Acute rheumatic fever (ARF) and rheumatic heart disease (RHD) create a global burden in the field of cardiovascular medicine due to significant morbidity and mortality, particularly in low- and middle-income countries and the underprivileged population.

Sequential surgical specimens of mitral valves excised from 19 patients with moderate to marked rheumatic mitral stenosis were included in this study and compared to eight sequential surgical myxomatous degenerative valves (control). The study group population had a mean age of 43.8 (± standard deviation (SD) 13.3) years and comprised 10 female and nine male patients. The controls included three female and five male patients with a mean age of 61.5 (± SD 16.1) years.

In RHD, the lymphatic vessel size and count per mm² were increased compared to the degenerative valves. Statistical significance was found in the blood and lymphatic vessel size, and lymphatic vessel count. In RHD, the combined blood and lymphatic vessel size increased from 1.45µm² (± SD 2.52) to 4.91 µm² (± SD 6.33). The lymphatic vessel count was 1,123.86 per mm² (± SD 2,154.68) in the RHD and 213.08 per mm² (± SD 390.13) in the myxomatous degenerative valves. Angiogenesis and lymphangiogenesis characterize mitral valves in RHD.

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风湿性二尖瓣血管生成和淋巴管生成增加。

急性风湿热（ARF）和风湿性心脏病（RHD）由于发病率和死亡率很高，在心血管医学领域造成了全球负担，特别是在低收入和中等收入国家和贫困人口中。本研究纳入了19例中度至明显风湿性二尖瓣狭窄患者的二尖瓣序贯手术标本，并与8例序贯手术粘液瘤性退行性二尖瓣（对照组）进行了比较。研究组患者平均年龄为43.8（±标准差13.3）岁，其中女性10例，男性9例。对照组包括3名女性和5名男性患者，平均年龄为61.5岁（±SD 16.1）岁。在RHD中，与退行性瓣膜相比，淋巴管的大小和每平方毫米的数量增加。血、淋巴管大小、淋巴管计数均有统计学意义。在RHD中，血管和淋巴管的总尺寸从1.45µm²（±SD 2.52）增加到4.91µm²（±SD 6.33）。RHD的淋巴管计数为1123.86 / mm²（±SD 2154.68），黏液瘤变性瓣膜的淋巴管计数为213.08 / mm²（±SD 390.13）。血管新生和淋巴管新生是RHD患者二尖瓣的特征。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiovascular Pathology 医学-病理学

CiteScore

7.50

自引率

2.70%

发文量

审稿时长

18 days

期刊介绍： Cardiovascular Pathology is a bimonthly journal that presents articles on topics covering the entire spectrum of cardiovascular disease. The Journal''s primary objective is to publish papers on disease-oriented morphology and pathogenesis from clinicians and scientists in the cardiovascular field. Subjects covered include cardiovascular biology, prosthetic devices, molecular biology and experimental models of cardiovascular disease.