Cost-Effectiveness of Personalised Nutrition in Adults With Overweight and Obesity: PREVENTOMICS Studies in Poland and the UK

IF 2.9 3区医学 Q3 NUTRITION & DIETETICS

Journal of Human Nutrition and Dietetics Pub Date : 2025-06-02 DOI:10.1111/jhn.70071

Milanne Maria Johanna Galekop, Philip C. Calder, Ella J. Baker, Joanna Góralska, Urszula Raźny, Malgorzata Malczewska-Malec, Carin A. Uyl-de Groot, William Ken Redekop

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引用次数: 0

Abstract

Background

We assessed the cost-effectiveness of personalised nutrition in adults with overweight/obesity in Poland and the United Kingdom (UK) using the results of two randomised controlled trials (RCTs).

Methods

The 4-month RCTs compared three interventions: personalised plan (PP) plus behavioural change (PP+B), PP only, and a control. Outcomes included body mass index (BMI), health-related quality of life (EQ-5D-5L), quality-adjusted life years (QALYs), and costs (2020 British pounds). A Markov model estimated lifetime cost-effectiveness. Different sensitivity analyses were performed.

Results

Participants were randomised to PP+B, PP, and control groups in Poland (n = 89, n = 88, n = 88) and the UK (n = 20, n = 19, n = 15). Comparing BMI reductions of PP+B and PP with control in both countries showed no significant differences, but wide confidence intervals (CIs) were observed (e.g., PP+B vs. control—Poland: −0.20, 95% CI: −0.86, 0.45 kg/m²; UK: −0.80, 95% CI: −1.60, 0.00 kg/m²). Lifetime analysis suggested potential cost-effectiveness for PP+B in Poland (£20,404 per QALY gain), and for PP+B (£13,006 per QALY) and PP (£12,222 per QALY) in the UK, since these figures were lower than the willingness-to-pay thresholds (£34,000 in Poland and £20,000 in the UK). PP in Poland was dominated by control, but sensitivity analyses suggested potential cost-effectiveness.

Conclusions

The PREVENTOMICS interventions may offer a cost-effective approach to reduce weight and avoid its related complications in both countries. Future studies should be larger and/or longer to reduce uncertainty about effectiveness.

Clinical Trial Registration Numbers: Poland ISRCTN51509551 and the UK ISRCTN46063864.

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超重和肥胖成人个性化营养的成本效益：波兰和英国的预防组学研究

背景：我们利用两项随机对照试验（RCTs）的结果，评估了波兰和英国超重/肥胖成人个性化营养的成本效益。方法：为期4个月的随机对照试验比较了三种干预措施：个性化计划（PP）加行为改变（PP+B），仅PP和对照。结果包括身体质量指数（BMI）、健康相关生活质量（EQ-5D-5L）、质量调整生命年（QALYs）和成本（2020英镑）。一个马尔可夫模型估计终身成本效益。进行不同的敏感性分析。在波兰（n = 89, n = 88, n = 88）和英国（n = 20, n = 19, n = 15），参与者被随机分为PP+B组、PP组和对照组。比较两国PP+B和PP与对照组的BMI降低没有显着差异，但观察到较宽的置信区间（CI）(例如，PP+B与对照波兰：- 0.20,95% CI: - 0.86, 0.45 kg/m2；UK:−0.80,95% CI:−1.60,0.00 kg/m2)。终身分析表明，波兰的PP+B（每个QALY收益20404英镑）、英国的PP+B（每个QALY收益13,006英镑）和PP（每个QALY收益12,222英镑）的潜在成本效益，因为这些数字低于支付意愿阈值（波兰34,000英镑和英国20,000英镑）。波兰的PP以控制为主，但敏感性分析表明潜在的成本效益。结论在这两个国家，PREVENTOMICS干预措施可能提供一种经济有效的方法来减轻体重并避免其相关并发症。未来的研究应该更大规模和/或更长时间，以减少有效性的不确定性。临床试验注册号：波兰ISRCTN51509551和英国ISRCTN46063864。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Human Nutrition and Dietetics 医学-营养学

CiteScore

5.30

自引率

15.20%

发文量

133

审稿时长

6-12 weeks

期刊介绍： Journal of Human Nutrition and Dietetics is an international peer-reviewed journal publishing papers in applied nutrition and dietetics. Papers are therefore welcomed on: - Clinical nutrition and the practice of therapeutic dietetics - Clinical and professional guidelines - Public health nutrition and nutritional epidemiology - Dietary surveys and dietary assessment methodology - Health promotion and intervention studies and their effectiveness - Obesity, weight control and body composition - Research on psychological determinants of healthy and unhealthy eating behaviour. Focus can for example be on attitudes, brain correlates of food reward processing, social influences, impulsivity, cognitive control, cognitive processes, dieting, psychological treatments. - Appetite, Food intake and nutritional status - Nutrigenomics and molecular nutrition - The journal does not publish animal research The journal is published in an online-only format. No printed issue of this title will be produced but authors will still be able to order offprints of their own articles.