Normal [¹⁸F]FE-PE2I PET in Patients with Persistent Diagnostic Uncertainty after Abnormal [¹²³I]FP-CIT SPECT.

Movement disorders : official journal of the Movement Disorder Society Pub Date : 2025-05-30 DOI:10.1002/mds.30255

Michiel Dhadamus, Aline Delva, Wies Deckers, Wim Vandenberghe, Koen Van Laere

{"title":"Normal [18F]FE-PE2I PET in Patients with Persistent Diagnostic Uncertainty after Abnormal [123I]FP-CIT SPECT.","authors":"Michiel Dhadamus, Aline Delva, Wies Deckers, Wim Vandenberghe, Koen Van Laere","doi":"10.1002/mds.30255","DOIUrl":null,"url":null,"abstract":"Background: In some patients with parkinsonism and abnormal dopamine transporter (DAT) imaging using [123I]FP-CIT single-photon emission computed tomography (SPECT), subsequent clinical evolution does not fit well with a neurodegenerative diagnosis.Objective: The objective was to analyze the results of positron emission tomography (PET) with the recently developed DAT radioligand [18F]FE-PE2I in patients with persistent diagnostic uncertainty despite an abnormal previous [123I]FP-CIT SPECT scan.Methods: This retrospective study included 19 patients with suspected parkinsonism and persistent diagnostic uncertainty after visually abnormal [123I]FP-CIT SPECT who subsequently underwent [18F]FE-PE2I PET (time between the two scans: 3.7 ± 2.2 years). Concordance between [123I]FP-CIT SPECT and [18F]FE-PE2I PET was determined after either purely visual assessment or semiquantitative analysis.Results: In 74% of cases with visually abnormal [123I]FP-CIT SPECT, [18F]FE-PE2I PET was visually normal. After semiquantitative analysis, 63% of cases with abnormal [123I]FP-CIT SPECT had normal [18F]FE-PE2I PET.Conclusions: [18F]FE-PE2I PET is normal in the majority of cases, with persistent diagnostic uncertainty after abnormal [123I]FP-CIT SPECT. © 2025 International Parkinson and Movement Disorder Society.","PeriodicalId":520713,"journal":{"name":"Movement disorders : official journal of the Movement Disorder Society","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Movement disorders : official journal of the Movement Disorder Society","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1002/mds.30255","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: In some patients with parkinsonism and abnormal dopamine transporter (DAT) imaging using [¹²³I]FP-CIT single-photon emission computed tomography (SPECT), subsequent clinical evolution does not fit well with a neurodegenerative diagnosis.

Objective: The objective was to analyze the results of positron emission tomography (PET) with the recently developed DAT radioligand [¹⁸F]FE-PE2I in patients with persistent diagnostic uncertainty despite an abnormal previous [¹²³I]FP-CIT SPECT scan.

Methods: This retrospective study included 19 patients with suspected parkinsonism and persistent diagnostic uncertainty after visually abnormal [¹²³I]FP-CIT SPECT who subsequently underwent [¹⁸F]FE-PE2I PET (time between the two scans: 3.7 ± 2.2 years). Concordance between [¹²³I]FP-CIT SPECT and [¹⁸F]FE-PE2I PET was determined after either purely visual assessment or semiquantitative analysis.

Results: In 74% of cases with visually abnormal [¹²³I]FP-CIT SPECT, [¹⁸F]FE-PE2I PET was visually normal. After semiquantitative analysis, 63% of cases with abnormal [¹²³I]FP-CIT SPECT had normal [¹⁸F]FE-PE2I PET.

Conclusions: [¹⁸F]FE-PE2I PET is normal in the majority of cases, with persistent diagnostic uncertainty after abnormal [¹²³I]FP-CIT SPECT. © 2025 International Parkinson and Movement Disorder Society.

查看原文本刊更多论文

正常[18F]FE-PE2I PET在异常[123I]FP-CIT SPECT后持续诊断不确定患者中的应用。

背景：在一些帕金森病患者中，使用[123I]FP-CIT单光子发射计算机断层扫描（SPECT）进行异常多巴胺转运体（DAT）成像，随后的临床发展与神经退行性诊断不太吻合。目的：目的是分析正电子发射断层扫描（PET）与最近发展的DAT放射配体[18F]FE-PE2I在持续诊断不确定的患者中的结果，尽管先前的[123I]FP-CIT SPECT扫描异常。方法：本回顾性研究纳入了19例疑似帕金森病并在视觉异常[123I]FP-CIT SPECT后持续诊断不确定的患者，这些患者随后接受了[18F]FE-PE2I PET检查（两次扫描间隔时间：3.7±2.2年）。[123I]FP-CIT SPECT与[18F]FE-PE2I PET之间的一致性通过纯目测或半定量分析来确定。结果：在[123I]FP-CIT SPECT视力异常的病例中，[18F]FE-PE2I PET视力正常的占74%。经半定量分析，在[123I]FP-CIT SPECT异常的病例中，有63%的[18F]FE-PE2I PET正常。结论：[18F]FE-PE2I PET在大多数病例中是正常的，[123I]FP-CIT SPECT异常后诊断持续不确定。©2025国际帕金森和运动障碍学会。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Movement disorders : official journal of the Movement Disorder Society

自引率

0.00%

发文量