The Patient Experience of Living With Knee Osteoarthritis Pain: Development of a Conceptual Model.

IF 1.6 Q3 RHEUMATOLOGY

Musculoskeletal Care Pub Date : 2025-06-01 DOI:10.1002/msc.70133

Chisom Kanu, Natalie V J Aldhouse, Ekin Seçinti, Hannah Edge, Katie Mellor, Katie Giblin, Rebecca Robinson, Julia Fraseur Brumm, Sarah L Knight

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引用次数: 0

Abstract

Background: Knee osteoarthritis (KOA) is a chronic degenerative condition. Pain is the most prominent symptom of KOA, which can be exacerbated by obesity. The US Food and Drug Administration recommends using patient-reported outcome (PRO) measures to assess KOA pain and function in clinical trials, but none have been validated for patients with KOA and obesity/overweight. The objective of this study was to explore and document the patient experience of signs, symptoms, and health-related quality of life (HRQoL) impacts of KOA pain, including the impact of obesity/overweight, to facilitate future validation studies.

Methods: A targeted literature review and interviews with US participants with KOA pain (including some with comorbid obesity) were conducted. Publications and interview transcripts were analysed using content analysis methods to develop a conceptual model of KOA pain experience.

Results: Eighteen publications were reviewed and 25 participants were interviewed. All participants in the interviews reported knee pain and described that their physical functioning had been negatively affected. Many experienced a negative emotional/psychological impact. Many participants believed that there was a relationship between their weight and experience of KOA pain, reporting a 'vicious cycle' of pain and weight gain due to KOA.

Conclusions: This study highlights the burden of living with KOA pain and the negative impact of obesity/overweight on patients' HRQoL. A conceptual model was developed, which may be used to explore the content validity of PRO measures and promote a robust understanding of the patient experience of living with KOA pain during the development of new therapies.

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膝关节骨关节炎疼痛患者的生活经验：一个概念模型的发展。

背景：膝骨关节炎（KOA）是一种慢性退行性疾病。疼痛是KOA最突出的症状，肥胖会加重这种症状。美国食品和药物管理局建议在临床试验中使用患者报告的结果（PRO）措施来评估KOA的疼痛和功能，但尚未对KOA和肥胖/超重患者进行验证。本研究的目的是探索和记录KOA疼痛对患者体征、症状和健康相关生活质量（HRQoL）的影响，包括肥胖/超重的影响，以促进未来的验证研究。方法：对美国KOA疼痛患者（包括一些合并肥胖患者）进行有针对性的文献回顾和访谈。使用内容分析方法对出版物和访谈记录进行分析，以建立KOA疼痛体验的概念模型。结果：回顾了18篇文献，访谈了25名参与者。所有的访谈参与者都报告了膝盖疼痛，并描述了他们的身体功能受到了负面影响。许多人经历了负面的情绪/心理影响。许多参与者认为他们的体重和KOA疼痛的经历之间存在关系，报告了由于KOA引起的疼痛和体重增加的“恶性循环”。结论：本研究突出了KOA疼痛患者的生活负担以及肥胖/超重对患者HRQoL的负面影响。我们开发了一个概念模型，用于探索PRO测量的内容效度，并在新疗法的开发过程中促进对KOA疼痛患者生活体验的全面理解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Musculoskeletal Care RHEUMATOLOGY-

CiteScore

2.30

自引率

7.70%

发文量

期刊介绍： Musculoskeletal Care is a peer-reviewed journal for all health professionals committed to the clinical delivery of high quality care for people with musculoskeletal conditions and providing knowledge to support decision making by professionals, patients and policy makers. This journal publishes papers on original research, applied research, review articles and clinical guidelines. Regular topics include patient education, psychological and social impact, patient experiences of health care, clinical up dates and the effectiveness of therapy.