{"title":"RAAS Overactivation and Mitochondrial Damage Signaling as Key Players in Lethal COVID-19.","authors":"Sabrina Fulkerson, Grace Hohman, Tyler Stark, Selman Aydogdu, Mohamed Eldeeb","doi":"10.2174/0113894501387212250525161808","DOIUrl":null,"url":null,"abstract":"<p><p>Coronavirus disease 2019 (COVID-19), which led to a global pandemic causing millions of deaths, is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV- -2). While previous research on COVID-19 has primarily utilized nasal swabs and blood samples, these do not provide comprehensive insights into all the organ systems affected by the infection. A recent study by Topper et al. addressed this gap by analyzing both nasal samples and autopsy tissues from SARS-CoV-2-infected individuals. Their findings highlight a significant role of mitochondrial damage pathways and RAAS overactivation in contributing to the severity of SARSCoV- 2 infections. Importantly, targeting mitochondrial dysfunction and RAAS overactivation pathways may offer promising and specific druggable targets for treating COVID-19 patients.</p>","PeriodicalId":10805,"journal":{"name":"Current drug targets","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current drug targets","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2174/0113894501387212250525161808","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Coronavirus disease 2019 (COVID-19), which led to a global pandemic causing millions of deaths, is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV- -2). While previous research on COVID-19 has primarily utilized nasal swabs and blood samples, these do not provide comprehensive insights into all the organ systems affected by the infection. A recent study by Topper et al. addressed this gap by analyzing both nasal samples and autopsy tissues from SARS-CoV-2-infected individuals. Their findings highlight a significant role of mitochondrial damage pathways and RAAS overactivation in contributing to the severity of SARSCoV- 2 infections. Importantly, targeting mitochondrial dysfunction and RAAS overactivation pathways may offer promising and specific druggable targets for treating COVID-19 patients.
期刊介绍：
Current Drug Targets aims to cover the latest and most outstanding developments on the medicinal chemistry and pharmacology of molecular drug targets e.g. disease specific proteins, receptors, enzymes, genes.
Current Drug Targets publishes guest edited thematic issues written by leaders in the field covering a range of current topics of drug targets. The journal also accepts for publication mini- & full-length review articles and drug clinical trial studies.
As the discovery, identification, characterization and validation of novel human drug targets for drug discovery continues to grow; this journal is essential reading for all pharmaceutical scientists involved in drug discovery and development.
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