Clinicopathological features and prognostic factors of AIDS-related lymphoma: a retrospective single-center study in China.

IF 2.4 3区医学 Q2 HEMATOLOGY

Annals of Hematology Pub Date : 2025-06-01 Epub Date: 2025-05-30 DOI:10.1007/s00277-025-06424-9

Ying Liang, Jing Chang, Yuxue Gao, Lin Sun, Zhujun Yue, Lingjia Meng, Caiping Guo, Yulin Zhang

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引用次数: 0

Abstract

AIDS-related lymphoma (ARL) is a leading cause of mortality among people living with HIV (PLWH), characterized by distinct clinicopathological features and a generally poor prognosis. However, comprehensive studies on ARL remain limited. This study aimed to evaluate the clinicopathological characteristics, immune status, and Epstein-Barr virus (EBV)/HIV viral loads in PLWH diagnosed with lymphoma, and to assess their prognostic significance. A retrospective analysis was conducted on 130 ARL cases diagnosed between 2017 and 2024. The cohort included 56 Burkitt lymphoma (BL), 51 diffuse large B-cell lymphoma (DLBCL), 9 Hodgkin lymphoma (HL), 8 plasmablastic lymphoma (PBL), and 6 T/NK cell lymphoma patients. The median age was 39 years, with 94.6% of patients being male. The 2-year overall survival (OS) rate was 50.6%, with HL showing the highest survival rate (85.7%) and BL the lowest (43.8%). Univariate analysis identified several factors significantly associated with poorer OS in non-Hodgkin lymphoma (NHL), including CD4 + T cell count < 200 cells/µL, presence of B symptoms, Eastern Cooperative Oncology Group (ECOG) performance status ≥ 2, elevated lactate dehydrogenase (LDH), Ann Arbor Stage III/IV disease, > 1 site with extranodal involvement, and bone marrow involvement (all P < 0.05). Multivariate analysis revealed that CD4 + T cell count < 200 cells/µL (HR: 2.085, P = 0.026) and elevated LDH (HR: 0.378, P = 0.005) were independent prognostic factors. In conclusion, NHL, particularly BL and DLBCL, is the predominant lymphoma subtype among PLWH. Severe immunodeficiency and elevated LDH may serve as effective prognostic factors for predicting OS in patients with AIDS-related NHL.

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中国艾滋病相关淋巴瘤的临床病理特征和预后因素：一项回顾性单中心研究。

艾滋病相关淋巴瘤（AIDS-related lymphoma， ARL）是HIV感染者（PLWH）死亡的主要原因，具有明显的临床病理特征和普遍较差的预后。然而，对ARL的全面研究仍然有限。本研究旨在评估诊断为淋巴瘤的PLWH的临床病理特征、免疫状态和eb病毒/HIV病毒载量，并评估其预后意义。回顾性分析了2017年至2024年诊断的130例ARL病例。该队列包括56例伯基特淋巴瘤（BL）， 51例弥漫性大b细胞淋巴瘤（DLBCL）， 9例霍奇金淋巴瘤（HL）， 8例浆母细胞淋巴瘤（PBL）和6例T/NK细胞淋巴瘤。中位年龄39岁，94.6%的患者为男性。2年总生存率（OS）为50.6%，其中HL生存率最高（85.7%），BL最低（43.8%）。单因素分析确定了与非霍奇金淋巴瘤（NHL）较差OS显著相关的几个因素，包括CD4 + T细胞计数1淋巴结外受累部位和骨髓受累(均P

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来源期刊

Annals of Hematology 医学-血液学

CiteScore

5.60

自引率

2.90%

发文量

304

审稿时长

2 months

期刊介绍： Annals of Hematology covers the whole spectrum of clinical and experimental hematology, hemostaseology, blood transfusion, and related aspects of medical oncology, including diagnosis and treatment of leukemias, lymphatic neoplasias and solid tumors, and transplantation of hematopoietic stem cells. Coverage includes general aspects of oncology, molecular biology and immunology as pertinent to problems of human blood disease. The journal is associated with the German Society for Hematology and Medical Oncology, and the Austrian Society for Hematology and Oncology.