Relationship between pericoronary fat attenuation index and quantitative plaque components in newly identified coronary plaques

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2025-05-27 DOI:10.1016/j.ejrad.2025.112206

Runzhi Zhang , Wenjing Zhao , Zehui Tang , Yan Xu , Hongyan Xie , Chuangwei Wei , Dongting Liu , Wei Dong , Jiayi Liu , Lei Xu , Zhaoying Wen , Nan Zhang

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引用次数: 0

Abstract

Purpose

This study investigates the correlation between fat attenuation index (FAI) and plaque components before and after coronary plaque formation in humans.

Methods

This retrospective study included 249 patients who developed newly identified coronary plaques after two coronary computed tomography angiography (CCTA) examinations, with the first yielding normal results. Vessels with newly identified plaques were categorized into the new plaque group, while others formed the no new plaque group. A control group of 50 patients with consistently normal CCTA results was also included. The new plaque group was further divided into stable FAI and progressive FAI groups based on changes in FAI.

Results

Before plaque formation, baseline FAI was highest in the new plaque group [(−80 (−84，-77) HU]. Baseline FAI was positively correlated with plaque volume, necrotic core volume, fibrofatty volume, and necrotic core percentage at both patient and vessel levels while showing a negative association with fibrous volume percentage (P < 0.05). After plaque formation, the percentage of necrotic core volume and diabetes mellitus were independent determinants of FAI increase in the patient level [OR: 1.31 (95 % CI: 1.12–––1.53) and OR: 3.07 (95 % CI: 1.14–––8.28), respectively]. At the vessel level, the percentage of necrotic core volume and fibrous volume were independent determinants of FAI increase [OR: 1.33 (95 % CI: 1.16–––1.53) and OR: 0.98 (95 % CI: 0.96–––0.99), respectively].

Conclusion

FAI was found to interact with the volume and components of newly formed coronary plaques, especially the necrotic core. A higher baseline FAI was associated with necrotic core formation, and the development of necrotic cores further increased FAI. Conversely, the formation of fibrous components appeared to mitigate the increase in FAI.

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新发现的冠状动脉斑块中冠状动脉脂肪衰减指数与定量斑块成分的关系

目的探讨人类冠状动脉斑块形成前后脂肪衰减指数（FAI）与斑块成分的相关性。方法本回顾性研究纳入249例在两次冠状动脉ct血管造影（CCTA）检查后出现新发现的冠状动脉斑块的患者，第一次检查结果正常。新发现斑块的血管被归类为新斑块组，而其他血管则形成无新斑块组。CCTA结果正常的50例患者也被纳入对照组。根据FAI的变化，将新斑块组进一步分为稳定FAI组和进行性FAI组。结果在斑块形成前，新斑块组的基线FAI最高[(- 80 (- 84,-77)HU]。基线FAI与患者和血管水平的斑块体积、坏死核心体积、纤维脂肪体积和坏死核心百分比呈正相关，而与纤维体积百分比呈负相关(P <；0.05)。斑块形成后，坏死核心体积百分比和糖尿病是患者FAI水平增加的独立决定因素[OR: 1.31 （95% CI: 1.12—1.53）和OR: 3.07 (95% CI: 1.14—8.28)]。在血管水平，坏死核心体积百分比和纤维体积百分比是FAI增加的独立决定因素[OR: 1.33 （95% CI: 1.16—1.53）和OR: 0.98 （95% CI: 0.96—0.99）分别]。结论fai与新形成的冠状动脉斑块的体积和组成相互作用，尤其是坏死核心。较高的基线FAI与坏死核的形成有关，坏死核的发展进一步增加了FAI。相反，纤维成分的形成似乎减轻了FAI的增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.