Identifying associated comorbidities in the development of trigeminal neuralgia: A propensity-matched analysis of the National Inpatient Sample

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Clinical Neurology and Neurosurgery Pub Date : 2025-05-26 DOI:10.1016/j.clineuro.2025.108985

Megan Tang, Alex Devarajan, Lily Huo, Tony Chung, Vikram Vasan, Jack Y. Zhang, Rui Feng, Emily Chapman, Joshua Bederson, Raj K. Shrivastava

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Abstract

Introduction

Trigeminal neuralgia (TN) is an uncommon disorder that leads to debilitating pain and interference with daily life. While often attributed to neurovascular compression, limited research has explored the underlying etiology and risk factors for TN. This study uses the National Inpatient Sample (NIS), the largest publicly-available administrative inpatient database in the United States, to examine demographics and comorbidities associated with TN, aiming to identify potential risk factors and vulnerable inpatient populations.

Methods

NIS data from 2016 to 2019 was searched for patients with a primary diagnosis of TN (ICD-10 G50.0). Demographics and comorbidities were identified. A 1:1 propensity match was performed between TN and non-TN patients based on demographics, hospital characteristics, and Charlson Comorbidity Index scores. Multivariable regression was performed to identify factors associated with TN and calculate adjusted odds ratios (OR).

Results

The final cohort included 38,300 patients, of whom 19,150 (50.0%) had TN. After matching, TN was significantly associated with multiple sclerosis (p < 0.001), other neurovascular compression disorders (NCD) including glossopharyngeal neuralgia and hemifacial spasm (p < 0.001), stroke (p < 0.001), systemic lupus erythematosus (p = 0.003), hyperlipidemia (p = 0.006), and complex diabetes (p < 0.001). Risk factors with the highest ORs included other NCDs (OR: 60.60, p < 0.001), multiple sclerosis (OR: 8.92, p < 0.001), and lupus (OR: 2.84, p = 0.003).

Conclusion

TN requiring hospitalization was independently associated with several comorbidities, including multiple sclerosis, lupus, stroke, hyperlipidemia, diabetes, and other NCDs. Notably, this is the first population-level study to identify an association between lupus and TN, highlighting a potential inflammatory component in TN pathophysiology. Prospective studies are warranted to further elucidate these associations.

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识别三叉神经痛发展的相关合并症：全国住院患者样本的倾向匹配分析

三叉神经痛（TN）是一种罕见的疾病，导致衰弱性疼痛和干扰日常生活。虽然通常归因于神经血管压迫，但有限的研究探索了TN的潜在病因和危险因素。本研究使用美国最大的公开行政住院患者数据库国家住院患者样本（NIS）来检查与TN相关的人口统计学和合并症，旨在确定潜在的危险因素和弱势住院患者人群。方法检索2016 - 2019年snis数据，纳入首发诊断为TN （ICD-10 G50.0）的患者。确定了人口统计学和合并症。根据人口统计学、医院特征和Charlson合并症指数评分，在TN和非TN患者之间进行1:1的倾向匹配。采用多变量回归确定与TN相关的因素，并计算校正优势比（OR）。ResultsThe最后的对象包括38300名患者,其中有19150 (50.0%)TN。匹配后,TN与多发性硬化症相关显著(p & lt; 0.001),其他神经与血管的压缩障碍(非传染性疾病),包括舌咽神经神经痛和半面痉挛(p & lt; 0.001),中风(p & lt; 0.001),系统性红斑狼疮(p = 0.003),高脂血症(p = 0.006),和复杂的糖尿病(p & lt; 0.001)。OR最高的危险因素包括其他非传染性疾病（OR: 60.60, p <； 0.001）、多发性硬化症（OR: 8.92, p <； 0.001）和狼疮（OR: 2.84, p = 0.003）。结论tn需要住院治疗与多种合并症独立相关，包括多发性硬化症、狼疮、中风、高脂血症、糖尿病和其他非传染性疾病。值得注意的是，这是首次确定狼疮与TN之间关联的人群水平研究，强调了TN病理生理中潜在的炎症成分。有必要进行前瞻性研究以进一步阐明这些关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurology and Neurosurgery 医学-临床神经学

CiteScore

3.70

自引率

5.30%

发文量

358

审稿时长

46 days

期刊介绍： Clinical Neurology and Neurosurgery is devoted to publishing papers and reports on the clinical aspects of neurology and neurosurgery. It is an international forum for papers of high scientific standard that are of interest to Neurologists and Neurosurgeons world-wide.