In vitro degradation, photo-activated antibacterial activity of sodium copper chlorophyllin crosslinked-polysilane composite coating on magnesium alloys

Corrosion Communications Pub Date : 2025-06-01 DOI:10.1016/j.corcom.2024.07.003

Lan-Yue Cui , Wei Wang , Zhen-Yu Zhang , Xue-Wen Jiang , Yu-Kun Du , Bo Liu , Shuo-Qi Li , Cheng-Bao Liu , Yong-Ming Xi , Rong-Chang Zeng

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Abstract

Non-invasive inactivation of bacteria by photodynamic therapy (PDT) and photothermal therapy (PTT) has been recently concerned for biomaterials. A polymethyltrimethoxysilane (PMTMS)-crosslinked sodium copper chlorophyllin (SCC) coating was prepared on micro arc oxidation (MAO) coated magnesium alloy AZ31 by one-step dipping method. Results showed that the MAO/PMTMS-SCC coating had high corrosion resistance with two magnitudes decrease in corrosion current density. Profound physical barrier and sealing effects of PMTMS-SCC coating in the initial stage of immersion prevented in-diffusion of Cu²⁺, thus, primeval renegaded Cu was released to corrosive solution, instead of triggering galvanic corrosion. Antibacterial ratios under irradiation of 808 nm near infrared light against E. coli and S. aureus were 99.6% and 99.1%, respectively, which is ascribed to a triple antibacterial mechanism. Such a composite coating also displays high biocompatibility, which will promote the application of magnesium alloys in biomedical fields.

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叶绿素铜钠-聚硅烷复合涂层在镁合金上的体外降解及光激活抗菌活性研究

利用光动力疗法（PDT）和光热疗法（PTT）对细菌进行无创灭活是近年来生物材料研究的热点。采用一步浸渍法在微弧氧化镁合金AZ31表面制备了聚甲基三甲氧基硅烷(PMTMS)-交联叶绿素铜钠（SCC）涂层。结果表明，MAO/PMTMS-SCC涂层具有较高的耐蚀性，腐蚀电流密度降低了2个数量级。PMTMS-SCC涂层在浸液初期具有较强的物理阻隔和密封作用，阻止了Cu2+的扩散，原始的还原态Cu被释放到腐蚀溶液中，而不是引发电偶腐蚀。808 nm近红外光照射下对大肠杆菌和金黄色葡萄球菌的抑菌率分别为99.6%和99.1%，具有三重抑菌机制。该复合涂层具有较高的生物相容性，将促进镁合金在生物医学领域的应用。

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来源期刊

Corrosion Communications

CiteScore

7.30

自引率

0.00%

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