Recovery and long-term health outcomes of SARS-CoV-2 infection in a prospective cohort in an urban setting, Kenya.

IF 2.2 3区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Global Health Action Pub Date : 2025-12-01 Epub Date: 2025-05-30 DOI:10.1080/16549716.2025.2500795

Isaac Kisiangani, Ângela Jornada Ben, Elke Wynberg, Welcome Wami, Samuel Iddi, Idah Kinya, Anna Vassall, Catherine Kyobutungi, Abdhalah Ziraba, John Njeru, Olive Mugenda, Marion Wangui Kiguoya, Mutambuki Kimondo, Geoffrey Githua, Menno D de Jong, Shukri F Mohamed, Gershim Asiki, Constance Schultsz

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引用次数: 0

Abstract

Background: Evidence on long COVID remains limited in sub-Saharan countries.

Objective: This study explored the occurrence of COVID-19-related symptoms and factors affecting recovery and long COVID severity in Nairobi, Kenya.

Methods: A prospective cohort of individuals testing positive for SARS-CoV-2 between February 2022 and February 2023 was followed until June 2023. COVID-19-related symptoms were assessed every three months. Time to recovery was analyzed using survival analysis, while factors affecting recovery factors and long COVID severity using Cox proportional hazard and Poisson regression, respectively.

Results: Among 291 participants (median age 34, 59.1% female), 42 (14%) had severe/critical infection. At 6 and 12 months post-positive PCR, 53.1% and 33.5% had ≥ 1 COVID-19-related symptoms, respectively. Fatigue (40.2%), pain (36.8%), sore throat (36.8%), headaches (36.4%), and loss of strength (31.6%) were most common. Median time to recovery was longer for severe/critical cases than mild/moderate (234 vs 206 days, p = 0.016). Participants aged 40-64 years experienced slower recovery than those aged < 40 years (aHR = 0.635 [95%CI, 0.429;0.941]). Participants with tertiary education recovered faster than those with primary education (aHR = 1.869 [95%CI, 1.050;3.327]). Long COVID severity was associated with female sex (aIRR = 1.418 [95%CI; 1.078;1.864]), tertiary education (aIRR, 0.489 [95%CI, 0.415;0.576]), and ≥ 1 comorbidity (aIRR = 2.415 [95%CI, 1.639;3.559]).

Conclusions: Six months post-infection, half had lingering symptoms, with a third still affected after a year. Recovery was faster in younger, educated individuals, while severe long COVID was more common in women, those with low education and pre-existing conditions. The burden of long COVID in Kenya requires support for vulnerable groups.

查看原文本刊更多论文

肯尼亚城市环境中前瞻性队列中SARS-CoV-2感染的恢复和长期健康结局

背景：在撒哈拉以南国家，关于长期COVID的证据仍然有限。目的：本研究探讨肯尼亚内罗毕地区新冠肺炎相关症状的发生情况、影响康复和长期严重程度的因素。方法：对2022年2月至2023年2月期间SARS-CoV-2检测呈阳性的个体进行前瞻性队列随访，直至2023年6月。每三个月评估一次covid -19相关症状。采用生存分析分析恢复时间，采用Cox比例风险回归和泊松回归分析影响恢复因素和长期病情严重程度的因素。结果：在291名参与者中（中位年龄34岁，女性59.1%），42名（14%）有严重/危重感染。PCR阳性后6个月和12个月，分别有53.1%和33.5%的人出现≥1种covid -19相关症状。最常见的是疲劳（40.2%）、疼痛（36.8%）、喉咙痛（36.8%）、头痛（36.4%）和力量丧失（31.6%）。重/危重病例的中位康复时间长于轻/中度病例（234天vs 206天，p = 0.016）。40-64岁的参与者比老年人恢复得慢。结论：感染后6个月，一半的人症状持续，三分之一的人在一年后仍然受到影响。受过教育的年轻人恢复得更快，而严重的长期COVID在女性、受教育程度低和已有疾病的人群中更为常见。肯尼亚长期的COVID负担需要对弱势群体提供支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Global Health Action PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-

CiteScore

5.10

自引率

3.80%

发文量

108

审稿时长

16 weeks

期刊介绍： Global Health Action is an international peer-reviewed Open Access journal affiliated with the Unit of Epidemiology and Global Health, Department of Public Health and Clinical Medicine at Umeå University, Sweden. The Unit hosts the Umeå International School of Public Health and the Umeå Centre for Global Health Research. Vision: Our vision is to be a leading journal in the global health field, narrowing health information gaps and contributing to the implementation of policies and actions that lead to improved global health. Aim: The widening gap between the winners and losers of globalisation presents major public health challenges. To meet these challenges, it is crucial to generate new knowledge and evidence in the field and in settings where the evidence is lacking, as well as to bridge the gaps between existing knowledge and implementation of relevant findings. Thus, the aim of Global Health Action is to contribute to fuelling a more concrete, hands-on approach to addressing global health challenges. Manuscripts suggesting strategies for practical interventions and research implementations where none already exist are specifically welcomed. Further, the journal encourages articles from low- and middle-income countries, while also welcoming articles originated from South-South and South-North collaborations. All articles are expected to address a global agenda and include a strong implementation or policy component.