Drug resistance and genetic transmission characteristics of HIV-1 CRF55_01B in people living with HIV/AIDS (PLWHA) in Henan Province, China.

IF 2.7 3区医学 Q3 VIROLOGY

Retrovirology Pub Date : 2025-05-29 DOI:10.1186/s12977-025-00665-2

Jie Ma, Jinjin Liu, Shuguang Wei, Mingjie Hou, Qingxia Zhao, Yuqi Huo

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引用次数: 0

Abstract

Background: Among the many CRFs, CRF55_01B was the first CRF01_AE and subtype B recombinant strain identified around 2013 among men who have sex with men (MSM) in Shenzhen, China. With rapid spreading throughout the country, CRF55_01B has attracted much attention in recent years. This study aimed to analyze its prevalence of drug resistance and transmission characteristics in people living with HIV/AIDS (PLWHA) in Henan province, China so as to pay particular attention to this group of individuals to reduce the incidence of drug resistance.

Results: Two hundred and forty-five CRF55_01B-infected individuals, including 141 treatment-naïve and 104 treatment-experienced individuals, were enrolled. In treatment-naïve individuals, 6.38% (9/141) of them harboured NRTI DRMs and 19.15% (27/141) of them harboured NNRTI DRMs except V179E/D. In treatment-experienced individuals, 2.00% (2/100) harboured INSTI DRMs, 82.69% (86/104) of them harboured NRTI DRMs, and 88.46% (92/104) of them harboured NNRTI DRMs except V179E/D. The overall prevalence of ADR was 89.42% (93/104), while the prevalence of PDR was 19.86% (28/141). A total of 23 transmission clusters, accounting for 37.55% (92/245) of the total sequences, were identified. The clusters ranged in size from 2 to 19, and 15 (65.22%) had 3 or more sequences.

Conclusions: High prevalence of DRMs and drug resistance were observed in CRF55_01B in both treatment-naïve and treatment-experienced individuals, particular attention should be paid to this group of individuals to reduce the incidence of drug resistance.

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河南省HIV-1 CRF55_01B在HIV/AIDS （PLWHA）感染者中的耐药性及遗传传播特征

背景：在众多crf中，CRF55_01B是2013年前后在中国深圳男男性行为者（MSM）中发现的首个CRF01_AE和B亚型重组菌株。近年来，CRF55_01B在全国范围内迅速传播，引起了人们的广泛关注。本研究旨在分析中国河南省HIV/AIDS感染者（PLWHA）的耐药情况及传播特点，以便对这一人群给予特别关注，降低耐药发生率。结果：纳入245名crf55_01b感染者，包括141名treatment-naïve和104名治疗经验丰富的个体。treatment-naïve个体中除V179E/D外，有6.38%（9/141）的个体携带NRTI drm，有19.15%（27/141）的个体携带NNRTI drm。有治疗经验的个体中，有2.00%（2/100）为INSTI drm， 82.69%（86/104）为NRTI drm， 88.46%（92/104）为除V179E/D外的NNRTI drm。ADR总发生率为89.42% (93/104)，PDR总发生率为19.86%（28/141）。共鉴定出23个传播聚类，占总序列的37.55%（92/245）。聚类的大小为2 ~ 19个，有3个及以上序列的聚类有15个（65.22%）。结论：CRF55_01B在treatment-naïve和有治疗经验的个体中均存在较高的drm患病率和耐药率，应特别注意这组个体，以减少耐药发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Retrovirology 医学-病毒学

CiteScore

5.80

自引率

3.00%

发文量

审稿时长

>0 weeks

期刊介绍： Retrovirology is an open access, online journal that publishes stringently peer-reviewed, high-impact articles on host-pathogen interactions, fundamental mechanisms of replication, immune defenses, animal models, and clinical science relating to retroviruses. Retroviruses are pleiotropically found in animals. Well-described examples include avian, murine and primate retroviruses. Two human retroviruses are especially important pathogens. These are the human immunodeficiency virus, HIV, and the human T-cell leukemia virus, HTLV. HIV causes AIDS while HTLV-1 is the etiological agent for adult T-cell leukemia and HTLV-1-associated myelopathy/tropical spastic paraparesis. Retrovirology aims to cover comprehensively all aspects of human and animal retrovirus research.