α-linolenic acid-induced facilitation of GABAergic synaptic transmission is mediated via acid-sensing ion channel (ASIC1a) activity in the basolateral amygdala.

IF 2.8 4区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Experimental Biology and Medicine Pub Date : 2025-05-15 eCollection Date: 2025-01-01 DOI:10.3389/ebm.2025.10545
Volodymyr I Pidoplichko, Taiza H Figueiredo, Maria F M Braga, Ann M Marini
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引用次数: 0

Abstract

Epilepsy affects more than 70 million people worldwide. A seizure focus that develops in different cortical brain regions can present as either focal or generalized seizures. Temporal lobe epilepsy is a highly pharmacoresistant form of epilepsy that involves the amygdala, hippocampus with or without hippocampal sclerosis as well as other limbic structures. Loss and/or dysfunction of GABAergic inhibitory neurons play a critical role in tipping the balance toward excitation. Synchronous burst firing is a feature of inhibitory neurons that is thought to regulate and rectify large excitatory neuronal networks in the BLA and is thought to underlie higher cognitive function. Acid sensing ion channels (ASIC) activated by decreases in pH, the presence of ammonium ion or a slight lowering of temperature are present on excitatory and inhibitory neurons and can alter excitability. The net effect of the activation of ASIC1a channels in the BLA is inhibition. ASIC1a channels are active in the basal state, enhancing primarily GABAergic inhibition by direct depolarization of interneurons but also by indirect excitation of interneurons via ASIC1a-mediated depolarization of pyramidal neurons. In this study, we examine the contribution of ASIC1a channel activation on alpha-linolenic acid (ALA)-induced GABAergic inhibitory synchronous burst firing in the BLA. Our results show that ALA initiates inhibitory bursts that are dependent, in part, on the activation of ASIC1a channels that may in turn be mediated by mature brain-derived neurotrophic factor.

α-亚麻酸诱导的gaba能突触传递是通过杏仁核基底外侧的酸感应离子通道(ASIC1a)活性介导的。
全世界有7000多万人患有癫痫。发作病灶发生在不同的大脑皮质区域,可表现为局灶性或全身性发作。颞叶癫痫是一种高度耐药的癫痫,涉及杏仁核、海马体(伴或不伴海马体硬化)以及其他边缘结构。gaba能抑制性神经元的丧失和/或功能障碍在将平衡转向兴奋方面起着关键作用。同步突发放电是抑制性神经元的一个特征,被认为是调节和纠正大兴奋性神经元网络在BLA,被认为是基础的高级认知功能。在兴奋性和抑制性神经元上存在酸感离子通道(ASIC),可通过pH值的降低、铵离子的存在或温度的轻微降低而激活,并可改变兴奋性。激活BLA中ASIC1a通道的净效应是抑制。ASIC1a通道在基础状态下是活跃的,主要通过中间神经元的直接去极化增强gaba能抑制,也通过ASIC1a介导的锥体神经元的去极化间接激发中间神经元。在这项研究中,我们研究了ASIC1a通道激活对α -亚麻酸(ALA)诱导的gaba能抑制同步突发放电的贡献。我们的研究结果表明,ALA启动的抑制爆发部分依赖于ASIC1a通道的激活,而ASIC1a通道可能反过来由成熟的脑源性神经营养因子介导。
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来源期刊
Experimental Biology and Medicine
Experimental Biology and Medicine 医学-医学:研究与实验
CiteScore
6.00
自引率
0.00%
发文量
157
审稿时长
1 months
期刊介绍: Experimental Biology and Medicine (EBM) is a global, peer-reviewed journal dedicated to the publication of multidisciplinary and interdisciplinary research in the biomedical sciences. EBM provides both research and review articles as well as meeting symposia and brief communications. Articles in EBM represent cutting edge research at the overlapping junctions of the biological, physical and engineering sciences that impact upon the health and welfare of the world''s population. Topics covered in EBM include: Anatomy/Pathology; Biochemistry and Molecular Biology; Bioimaging; Biomedical Engineering; Bionanoscience; Cell and Developmental Biology; Endocrinology and Nutrition; Environmental Health/Biomarkers/Precision Medicine; Genomics, Proteomics, and Bioinformatics; Immunology/Microbiology/Virology; Mechanisms of Aging; Neuroscience; Pharmacology and Toxicology; Physiology; Stem Cell Biology; Structural Biology; Systems Biology and Microphysiological Systems; and Translational Research.
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