Adherence to Multidisciplinary Tumor Board Recommendations and Its Association with Survival: A Retrospective Observational Study of Colorectal Cancer Patients.

IF 1.6 Q4 ONCOLOGY

Journal of Gastrointestinal Cancer Pub Date : 2025-05-30 DOI:10.1007/s12029-025-01246-4

Esin Aysel Kandemir, Julia Roeper, Heiner Zimmermann, Lena Ansmann, Petra Hülper, Maximilian Bockhorn, Claus-Henning Köhne, Frank Griesinger

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引用次数: 0

Abstract

Purpose: Multidisciplinary tumor boards (MTBs) intend to increase the quality of cancer care. Research on the association of adherence to MTB recommendations with survival is limited. This study aims to determine the impact of adherence to MTB recommendations on survival in colorectal cancer patients.

Methods: This is a retrospective, observational study including patients diagnosed between 01.01.2014 and 31.12.2018. Electronic health records were reviewed to determine the adherence. Study endpoints were adherence rate, disease-free survival (DFS), and overall survival (OS). Follow-up was performed until 12.12.2023.

Results: There was a significant difference in DFS (median DFS: 79 months [95% CI, 73-89] vs 22 months [95% CI, 17-87]) and OS (median OS: 78 months [95% CI, 75-86] vs 65 months [95% CI, 28-NR]) between the adherent group (n=406) versus the non-adherent group (n=52) (log-rank test, p<0.05). Performance status, stage and non-adherence were independent predictors of survival in the multivariate analysis (p<0.05 for all). The most common reason for non-adherence was patient preference (n=23).

Conclusion: While MTBs have become an indispensable part of clinical practice, adherence to MTB recommendations was crucial to achieve survival benefit in this study. Patient preference should be prospectively analyzed from a patient and caregiver perspective in future studies.

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遵守多学科肿瘤委员会建议及其与生存的关系：结直肠癌患者的回顾性观察研究。

目的：多学科肿瘤委员会（MTBs）旨在提高癌症治疗的质量。关于坚持MTB建议与生存之间关系的研究是有限的。本研究旨在确定坚持MTB建议对结直肠癌患者生存的影响。方法：这是一项回顾性观察性研究，纳入2014年1月1日至2018年12月31日诊断的患者。审查电子健康记录以确定依从性。研究终点是依从率、无病生存期（DFS）和总生存期（OS）。随访至2023年12月12日。结果：粘附组（n=406）与非粘附组（n=52）的DFS（中位DFS: 79个月[95% CI， 73-89] vs . 22个月[95% CI， 17-87]）和OS（中位OS: 78个月[95% CI， 75-86] vs . 65个月[95% CI， 28-NR]）存在显著差异（对数秩检验，p）。结论：虽然MTB已成为临床实践中不可或缺的一部分，但在本研究中，遵守MTB建议对于获得生存益处至关重要。在今后的研究中，应从患者和护理者的角度对患者偏好进行前瞻性分析。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gastrointestinal Cancer ONCOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

121

期刊介绍： The Journal of Gastrointestinal Cancer is a multidisciplinary medium for the publication of novel research pertaining to cancers arising from the gastrointestinal tract.The journal is dedicated to the most rapid publication possible.The journal publishes papers in all relevant fields, emphasizing those studies that are helpful in understanding and treating cancers affecting the esophagus, stomach, liver, gallbladder and biliary tree, pancreas, small bowel, large bowel, rectum, and anus. In addition, the Journal of Gastrointestinal Cancer publishes basic and translational scientific information from studies providing insight into the etiology and progression of cancers affecting these organs. New insights are provided from diverse areas of research such as studies exploring pre-neoplastic states, risk factors, epidemiology, genetics, preclinical therapeutics, surgery, radiation therapy, novel medical therapeutics, clinical trials, and outcome studies.In addition to reports of original clinical and experimental studies, the journal also publishes: case reports, state-of-the-art reviews on topics of immediate interest or importance; invited articles analyzing particular areas of pancreatic research and knowledge; perspectives in which critical evaluation and conflicting opinions about current topics may be expressed; meeting highlights that summarize important points presented at recent meetings; abstracts of symposia and conferences; book reviews; hypotheses; Letters to the Editors; and other items of special interest, including:Complex Cases in GI Oncology: This is a new initiative to provide a forum to review and discuss the history and management of complex and involved gastrointestinal oncology cases. The format will be similar to a teaching case conference where a case vignette is presented and is followed by a series of questions and discussion points. A brief reference list supporting the points made in discussion would be expected.