From cranes to crutches: the disabling potential of necrotising myopathy.

IF 0.6 Q3 MEDICINE, GENERAL & INTERNAL

BMJ Case Reports Pub Date : 2025-05-28 DOI:10.1136/bcr-2024-262878

Jessica Liang, Leslie Lin, Tanushri Bhushan, Mazhar Shapoo, Arabi Rasendrakumar

引用次数: 0

Abstract

We present a case of a middle-aged man with progressive bilateral proximal muscle weakness. Laboratory studies showed a creatine kinase level of 22 000 units/L and hydroxy-3-methylglutaryl-CoA reductase (HMGCR) antibody IgG of 109 units. Muscle biopsy revealed necrotic fibres undergoing phagocytosis as well as mixed regenerated and atrophic muscle fibres. The diagnosis of HMGCR necrotising myopathy was confirmed, with marked clinical improvement following mycophenolate mofetil and intravenous immunoglobulin therapy.

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从起重机到拐杖：坏死性肌病的致残潜力。

我们提出一例中年男子进行性双侧近端肌无力。实验室检查显示肌酸激酶水平为22000单位/L，羟-3-甲基戊二酰辅酶a还原酶（HMGCR）抗体IgG为109单位。肌肉活检显示坏死纤维被吞噬，以及混合再生和萎缩肌纤维。确诊为HMGCR坏死性肌病，经霉酚酸酯及静脉注射免疫球蛋白治疗后临床明显好转。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMJ Case Reports Medicine-Medicine (all)

CiteScore

1.40

自引率

0.00%

发文量

1588

期刊介绍： BMJ Case Reports is an important educational resource offering a high volume of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions. All articles are peer reviewed and copy edited before publication. BMJ Case Reports is not an edition or supplement of the BMJ.