Hypereosinophilic Syndrome Presenting with Digestive Symptoms in Pediatric Patients: A Portuguese Tertiary Hospital Case Series.

IF 1 Q4 GASTROENTEROLOGY & HEPATOLOGY

GE Portuguese Journal of Gastroenterology Pub Date : 2025-04-21 DOI:10.1159/000545921

Maria Sousa, Sara Catarino, Céu Espinheira, Mariana Rodrigues, Fátima Ferreira, Eunice Trindade

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引用次数: 0

Abstract

Introduction: Hypereosinophilic syndrome (HES) is an uncommon disorder characterized by persistent peripheral eosinophilia and involvement of different organs. It is rare in pediatric ages.

Cases presentation: We present 3 pediatric patients diagnosed with HES exhibiting digestive symptoms. Clinical records, laboratory results, imaging studies, and treatment plans were systematically collected and analyzed. All patients underwent an extensive etiological investigation to exclude infectious, autoimmune, and tumoral causes. Treatment with corticosteroids resulted in symptomatic and analytical improvement in all patients.

Conclusion: This case series highlights the complexity of pediatric HES presenting with digestive manifestations. The diverse clinical presentation underscores the importance of considering HES in the differential diagnosis of unexplained gastrointestinal symptoms in children. Diagnostic and treatment challenges demand a multidisciplinary approach. These insights enhance our knowledge of this rare condition, enlarging the limited literature on this subject in the pediatric population.

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高嗜酸性粒细胞综合征呈现消化症状的儿科患者：葡萄牙三级医院病例系列。

高嗜酸性粒细胞综合征（HES）是一种罕见的疾病，其特征是持续的外周嗜酸性粒细胞增多和累及不同器官。这在儿童年龄是罕见的。病例介绍：我们报告了3例被诊断为HES的儿童患者，他们表现出消化系统症状。系统收集和分析临床记录、实验室结果、影像学检查和治疗方案。所有患者都进行了广泛的病因学调查，以排除感染、自身免疫和肿瘤原因。皮质类固醇治疗导致所有患者的症状和分析性改善。结论：本病例系列突出了以消化道表现为表现的儿科HES的复杂性。不同的临床表现强调了在儿童不明原因胃肠道症状的鉴别诊断中考虑HES的重要性。诊断和治疗挑战需要多学科的方法。这些见解增强了我们对这种罕见疾病的认识，扩大了儿科人群中关于这一主题的有限文献。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

GE Portuguese Journal of Gastroenterology GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

1.60

自引率

11.10%

发文量

审稿时长

21 weeks

期刊介绍： The ''GE Portuguese Journal of Gastroenterology'' (formerly Jornal Português de Gastrenterologia), founded in 1994, is the official publication of Sociedade Portuguesa de Gastrenterologia (Portuguese Society of Gastroenterology), Sociedade Portuguesa de Endoscopia Digestiva (Portuguese Society of Digestive Endoscopy) and Associação Portuguesa para o Estudo do Fígado (Portuguese Association for the Study of the Liver). The journal publishes clinical and basic research articles on Gastroenterology, Digestive Endoscopy, Hepatology and related topics. Review articles, clinical case studies, images, letters to the editor and other articles such as recommendations or papers on gastroenterology clinical practice are also considered. Only articles written in English are accepted.