Emerging roles of ribosome translation in stem cells and stem cell therapy - a review.

IF 6.2 2区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell and Bioscience Pub Date : 2025-05-28 DOI:10.1186/s13578-025-01412-y

Yanyan Gao, Linlin Guo, Gaoxiang Shi, Ruifang Wang, Xu'an Wang, Jizhong Lou

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引用次数: 0

Abstract

Stem cells differ from other somatic cells in that they possess self-renewal and differentiation potential, which endows them with unique characteristics, and have great therapeutic potential. Studies have shown that the self-renewal and differentiation potential of stem cells is regulated by ribosomes during protein synthesis. In this review, we discuss the translation regulation mechanisms and ribosome biogenesis in stem cells. Protein translation levels and ribosome biogenesis change dynamically during the development and differentiation of stem cells, and hierarchical translational regulation promotes stem cell differentiation. We also demonstrate that mitochondrial protein translation plays an important role in the regulation of stem cell fate. Ribosomes not only mediate the self-renewal and differentiation of stem cells through protein synthesis. They are also a key target for stem cell therapy. Understanding the mechanism of ribosome regulation in stem cells will allow better control of stem cells for their application.

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核糖体翻译在干细胞和干细胞治疗中的新作用综述。

干细胞与其他体细胞的不同之处在于它具有自我更新和分化的能力，这使其具有独特的特性，具有很大的治疗潜力。研究表明，干细胞的自我更新和分化潜能在蛋白质合成过程中受到核糖体的调节。本文就干细胞中核糖体的翻译调控机制和核糖体的生物发生作一综述。在干细胞的发育和分化过程中，蛋白质翻译水平和核糖体生物发生是动态变化的，分层翻译调控促进了干细胞的分化。我们还证明了线粒体蛋白翻译在干细胞命运的调控中起着重要作用。核糖体不仅通过蛋白质合成介导干细胞的自我更新和分化。它们也是干细胞治疗的关键靶点。了解核糖体在干细胞中的调控机制将有助于更好地控制干细胞的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell and Bioscience BIOCHEMISTRY & MOLECULAR BIOLOGY-

CiteScore

10.70

自引率

0.00%

发文量

187

审稿时长

>12 weeks

期刊介绍： Cell and Bioscience, the official journal of the Society of Chinese Bioscientists in America, is an open access, peer-reviewed journal that encompasses all areas of life science research.