Julian Freier, Leon Brückner, Bastian Löhrl, Maya Shariff, Luitpold Distel, Christoph Bert, Peter Hommelhoff
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combine high relative biological effectiveness (RBE) with low penetration depth in
tissue, making them an interesting tool for radiobiological studies. To harness these
advantages, a reliable and comprehensible dosimetry method is essential.
Approach Unlaminated EBT3 GafChromic films were evaluated as potential LEE
dosimeters, given the limitations of other dosimetry tools for LEE applications. The
depth dose profile of the LEE in the film was simulated and then combined with the
experimentally determined response of the film to a calibrated radiation source. Using
this, the total response of the film for a given average dose was calculated.
Main results A calibration curve for unlaminated EBT3 GafChromic films for LEE in
the energy range of 12 keV to 45 keV has been successfully developed for a range of
average doses from 0 Gy to 16 Gy.
Significance The developed calibration curve enables direct, quantitative comparison
of biological experiments using LEE with other types of radiation such as x-rays,
facilitating the adoption of LEE in radiobiological research.</p>","PeriodicalId":20185,"journal":{"name":"Physics in medicine and biology","volume":" ","pages":""},"PeriodicalIF":3.3000,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Physics in medicine and biology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1088/1361-6560/adde28","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective Low energy electrons (LEE) in the range of tens of keV
combine high relative biological effectiveness (RBE) with low penetration depth in
tissue, making them an interesting tool for radiobiological studies. To harness these
advantages, a reliable and comprehensible dosimetry method is essential.
Approach Unlaminated EBT3 GafChromic films were evaluated as potential LEE
dosimeters, given the limitations of other dosimetry tools for LEE applications. The
depth dose profile of the LEE in the film was simulated and then combined with the
experimentally determined response of the film to a calibrated radiation source. Using
this, the total response of the film for a given average dose was calculated.
Main results A calibration curve for unlaminated EBT3 GafChromic films for LEE in
the energy range of 12 keV to 45 keV has been successfully developed for a range of
average doses from 0 Gy to 16 Gy.
Significance The developed calibration curve enables direct, quantitative comparison
of biological experiments using LEE with other types of radiation such as x-rays,
facilitating the adoption of LEE in radiobiological research.
期刊介绍:
The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry