Dosimetry for low energy electrons in the range of 12 to 45 keV with EBT3 GafChromic films.

IF 3.3 3区 医学 Q2 ENGINEERING, BIOMEDICAL
Julian Freier, Leon Brückner, Bastian Löhrl, Maya Shariff, Luitpold Distel, Christoph Bert, Peter Hommelhoff
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Abstract

Objective Low energy electrons (LEE) in the range of tens of keV combine high relative biological effectiveness (RBE) with low penetration depth in tissue, making them an interesting tool for radiobiological studies. To harness these advantages, a reliable and comprehensible dosimetry method is essential. Approach Unlaminated EBT3 GafChromic films were evaluated as potential LEE dosimeters, given the limitations of other dosimetry tools for LEE applications. The depth dose profile of the LEE in the film was simulated and then combined with the experimentally determined response of the film to a calibrated radiation source. Using this, the total response of the film for a given average dose was calculated. Main results A calibration curve for unlaminated EBT3 GafChromic films for LEE in the energy range of 12 keV to 45 keV has been successfully developed for a range of average doses from 0 Gy to 16 Gy. Significance The developed calibration curve enables direct, quantitative comparison of biological experiments using LEE with other types of radiation such as x-rays, facilitating the adoption of LEE in radiobiological research.

用EBT3 GafChromic薄膜对12 ~ 45kev范围内的低能电子进行剂量测定。
目的:数十kv范围内的低能电子(LEE)结合了高相对生物有效性(RBE)和在组织中的低穿透深度,使其成为一种有趣的放射生物学研究工具。为了利用这些优势,一种可靠且易于理解的剂量测定方法是必不可少的。考虑到其他剂量测定工具在LEE应用中的局限性,我们评估了未层压EBT3 GafChromic薄膜作为潜在的LEE剂量计。模拟了薄膜中LEE的深度剂量分布,然后将其与实验确定的薄膜对校准辐射源的响应相结合。利用该方法,计算了给定平均剂量下薄膜的总响应。主要结果在12 ~ 45 keV的能量范围内,在0 ~ 16 Gy的平均剂量范围内,成功地建立了用于LEE的未层压EBT3 GafChromic薄膜的校准曲线。将使用LEE进行的生物实验与其他类型的辐射(如x射线)进行定量比较,促进LEE在放射生物学研究中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Physics in medicine and biology
Physics in medicine and biology 医学-工程:生物医学
CiteScore
6.50
自引率
14.30%
发文量
409
审稿时长
2 months
期刊介绍: The development and application of theoretical, computational and experimental physics to medicine, physiology and biology. Topics covered are: therapy physics (including ionizing and non-ionizing radiation); biomedical imaging (e.g. x-ray, magnetic resonance, ultrasound, optical and nuclear imaging); image-guided interventions; image reconstruction and analysis (including kinetic modelling); artificial intelligence in biomedical physics and analysis; nanoparticles in imaging and therapy; radiobiology; radiation protection and patient dose monitoring; radiation dosimetry
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