Melatonin Supplementation in Alzheimer's disease: The Potential Role in Neurogenesis.

IF 4.3 2区医学 Q1 NEUROSCIENCES

Molecular Neurobiology Pub Date : 2025-11-01 Epub Date: 2025-05-29 DOI:10.1007/s12035-025-05095-x

Rasoul Ebrahimi, Ali Faramarzi, Shakiba Salarvandian, Reyhaneh Zarei, Moghadaseh Heidari, Fatemeh Salehian, Khadijeh Esmaeilpour

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引用次数: 0

Abstract

Melatonin supplementation shows potential therapeutic effects in Alzheimer's disease (AD) by targeting impaired neurogenesis. Neurogenesis, the formation of new neurons after development, involves proliferation, migration, differentiation, and survival of neurons. Impaired neurogenesis is associated with AD, specifically in the subventricular zone (SVZ) and subgranular zone (SGZ), leading to hippocampal degeneration and memory impairment. Melatonin positively effects AD by regulating amyloid beta (Aβ)-induced neuroinflammation, reducing tau hyperphosphorylation, and enhancing adult neurogenesis through various signaling pathways. In addition, it has anti-apoptotic, antioxidative, and anti-inflammatory properties, suggesting its potential as a treatment option for AD progression. Furthermore, melatonin and sleep are closely linked, and an increase in sleep duration positively affects Aβ deposition. This review aims to examine the impact of AD pathologies on neurogenesis and explore the mechanisms by which melatonin may alleviate these pathologies, potentially promoting neurogenesis.

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补充褪黑素治疗阿尔茨海默病：在神经发生中的潜在作用。

褪黑素补充剂通过靶向受损的神经发生在阿尔茨海默病（AD）中显示出潜在的治疗效果。神经发生是新神经元在发育后形成的过程，涉及神经元的增殖、迁移、分化和存活。神经发生受损与AD相关，特别是在室下区（SVZ）和亚颗粒区（SGZ），导致海马变性和记忆障碍。褪黑素通过多种信号通路调节β淀粉样蛋白（Aβ）诱导的神经炎症，减少tau过度磷酸化，促进成人神经发生，从而对AD产生积极作用。此外，它还具有抗凋亡、抗氧化和抗炎的特性，这表明它有可能成为治疗AD进展的一种选择。此外，褪黑激素与睡眠密切相关，睡眠时间的增加对Aβ沉积有积极影响。本综述旨在研究AD病理对神经发生的影响，并探讨褪黑素减轻这些病理的机制，可能促进神经发生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Neurobiology 医学-神经科学

CiteScore

9.00

自引率

2.00%

发文量

480

审稿时长

1 months

期刊介绍： Molecular Neurobiology is an exciting journal for neuroscientists needing to stay in close touch with progress at the forefront of molecular brain research today. It is an especially important periodical for graduate students and "postdocs," specifically designed to synthesize and critically assess research trends for all neuroscientists hoping to stay active at the cutting edge of this dramatically developing area. This journal has proven to be crucial in departmental libraries, serving as essential reading for every committed neuroscientist who is striving to keep abreast of all rapid developments in a forefront field. Most recent significant advances in experimental and clinical neuroscience have been occurring at the molecular level. Until now, there has been no journal devoted to looking closely at this fragmented literature in a critical, coherent fashion. Each submission is thoroughly analyzed by scientists and clinicians internationally renowned for their special competence in the areas treated.