Postoperative stellate ganglion block reduces high-sensitivity troponin T release in patients undergoing off-pump coronary artery bypass surgery: a randomized controlled trial.

IF 2.9 3区医学 Q1 ANESTHESIOLOGY

Minerva anestesiologica Pub Date : 2025-05-29 DOI:10.23736/S0375-9393.25.18748-8

Yujie Zhu, Xiaozhe Zhu, Luyao Wang, Lei Shen, Dunyi Qi

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Abstract

Background: The non-analgesic applications of stellate ganglion block (SGB) are increasingly garnering scholarly and clinical interest. This study aimed to investigate the myocardial protective effects of postoperative SGB in patients undergoing off-pump coronary artery bypass grafting (OPCABG).

Methods: In this double-blind, randomized controlled trial, 62 adults scheduled for OPCABG were randomized to one of two groups: the right stellate ganglion block group (RSGB group) and the control group. Postoperation, participants had a right SGB. However, controls were not blocked. The primary outcome was serum high-sensitivity troponin T concentration measured within seven days after surgery. Secondary outcomes included postoperative hemodynamics, postoperative pain scores, postoperative incidence of atrial fibrillation, postoperative dosage of vasoactive drugs, postoperative opioid consumption, incidence of myocardial infarction, 30-day postoperative mortality, and length of hospital stay.

Results: At some point after the operation, the RSGB group patients' serum high-sensitivity troponin levels were noticeably lower than the control group, with means (standard deviation [SD]) of 146.1 (49.7) vs. 207.8 (50.6) at 12 hours; 132.7 (35.6) vs. 202.6 (43.8) at 24 hours; 19.7 (9.2) vs. 41.7 (24.7) at 7 days; all P<0.001. Moreover, the RSGB group showed significantly lower pain scores, a significantly reduced postoperative rate-pressure product (RPP) value, and a substantially lower incidence of atrial fibrillation.

Conclusions: In patients undergoing OPCABG, it was observed that postoperative right SGB can reduce postoperative high-sensitivity cardiac troponin T levels.

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术后星状神经节阻滞减少非体外循环冠状动脉搭桥手术患者高敏感性肌钙蛋白T释放：一项随机对照试验

背景：星状神经节阻滞（SGB）的非镇痛应用越来越受到学术和临床的关注。本研究旨在探讨SGB在非体外循环冠状动脉旁路移植术（OPCABG）患者术后的心肌保护作用。方法：在本双盲、随机对照试验中，62例计划行OPCABG的成年人随机分为两组：右星状神经节阻滞组（RSGB组）和对照组。术后，受试者SGB正常。然而，控制并没有被阻止。主要终点是术后7天内测定的血清高敏肌钙蛋白T浓度。次要结局包括术后血流动力学、术后疼痛评分、术后房颤发生率、术后血管活性药物用量、术后阿片类药物用量、心肌梗死发生率、术后30天死亡率和住院时间。结果：术后某时点，RSGB组患者血清高敏肌钙蛋白水平明显低于对照组，12 h时均值（标准差[SD]）为146.1（49.7）比207.8 (50.6)；24小时时132.7（35.6）比202.6 (43.8)；19.7 (9.2) vs. 41.7 (24.7)；结论：在OPCABG患者中，观察到术后右侧SGB可降低术后高敏感性心肌肌钙蛋白T水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Minerva anestesiologica 医学-麻醉学

CiteScore

4.50

自引率

21.90%

发文量

367

审稿时长

4-8 weeks

期刊介绍： Minerva Anestesiologica is the journal of the Italian National Society of Anaesthesia, Analgesia, Resuscitation, and Intensive Care. Minerva Anestesiologica publishes scientific papers on Anesthesiology, Intensive care, Analgesia, Perioperative Medicine and related fields. Manuscripts are expected to comply with the instructions to authors which conform to the Uniform Requirements for Manuscripts Submitted to Biomedical Editors by the International Committee of Medical Journal Editors.