Multi-model quantitative MRI of uterine cancers in precision medicine's era-a narrative review.

IF 4.1 2区 医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Marco Gennarini, Rossella Canese, Silvia Capuani, Valentina Miceli, Federica Tomao, Innocenza Palaia, Valentina Zecca, Alessandra Maiuro, Ilaria Balba, Carlo Catalano, Stefania Maria Rita Rizzo, Lucia Manganaro
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引用次数: 0

Abstract

Purpose: This review aims to summarize the current applications of quantitative MRI biomarkers in the staging, treatment response evaluation, and prognostication of endometrial (EC) and cervical cancer (CC). By focusing on functional imaging techniques, we explore how these biomarkers enhance personalized cancer management beyond traditional morphological assessments.

Methods: A structured search of the PubMed database from January to May 2024 was conducted to identify relevant studies on quantitative MRI in uterine cancers. We included studies examining MRI biomarkers like Dynamic Contrast-Enhanced MRI (DCE-MRI), Diffusion-Weighted Imaging (DWI), and Magnetic Resonance Spectroscopy (MRS), emphasizing their roles in assessing tumor physiology, microstructure, and metabolic changes.

Results: DCE-MRI provides valuable quantitative biomarkers such as Ktrans and Ve, which reflect microvascular characteristics and tumor aggressiveness, outperforming T2-weighted imaging in detecting critical factors like myometrial and cervical invasion. DWI, including advanced models like Intravoxel Incoherent Motion (IVIM), distinguishes between normal and cancerous tissue and correlates with tumor grade and treatment response. MRS identifies metabolic alterations, such as elevated choline and lipid signals, which serve as prognostic markers in uterine cancers.

Conclusion: Quantitative MRI offers a noninvasive method to assess key biomarkers that inform prognosis and guide treatment decisions in uterine cancers. By providing insights into tumor biology, these imaging techniques represent a significant step forward in the precision medicine era, allowing for a more tailored therapeutic approach based on the unique pathological and molecular characteristics of each tumor.

Critical relevance statement: Biomarkers obtained from MRI can provide useful quantitative information about the nature of uterine cancers and their prognosis, both at diagnosis and response assessment, allowing better therapeutic strategies to be prepared.

Key points: Quantitative MRI improves diagnosis and management of uterine cancers through advanced imaging biomarkers. Quantitative MRI biomarkers enhance staging, prognosis, and treatment response assessment in uterine cancers. Quantitative MRI biomarkers support personalized treatment strategies and improve patient management in uterine cancers.

精准医学时代子宫癌多模型定量MRI研究述评。
目的:综述定量MRI生物标志物在子宫内膜癌(EC)和宫颈癌(CC)分期、治疗反应评价和预后方面的应用现状。通过关注功能成像技术,我们探索这些生物标志物如何在传统形态学评估之外增强个性化癌症管理。方法:对2024年1 - 5月PubMed数据库进行结构化检索,识别子宫癌定量MRI相关研究。我们纳入了MRI生物标志物的研究,如动态对比增强MRI (DCE-MRI)、扩散加权成像(DWI)和磁共振波谱(MRS),强调了它们在评估肿瘤生理、微观结构和代谢变化方面的作用。结果:DCE-MRI提供了有价值的定量生物标志物,如Ktrans和Ve,反映微血管特征和肿瘤侵袭性,在检测肌内膜和宫颈浸润等关键因素方面优于t2加权成像。DWI,包括像IVIM这样的高级模型,可以区分正常组织和癌组织,并与肿瘤分级和治疗反应相关。MRS可识别代谢改变,如胆碱和脂质信号升高,作为子宫癌的预后标志物。结论:定量MRI提供了一种无创的方法来评估子宫癌预后和指导治疗决策的关键生物标志物。通过深入了解肿瘤生物学,这些成像技术代表了精准医学时代的重要一步,允许基于每个肿瘤独特的病理和分子特征的更有针对性的治疗方法。关键相关性声明:从MRI中获得的生物标志物可以提供有关子宫癌性质及其预后的有用定量信息,无论是在诊断还是反应评估方面,都可以制定更好的治疗策略。重点:定量MRI通过先进的成像生物标志物提高子宫癌的诊断和治疗。定量MRI生物标志物增强子宫癌的分期、预后和治疗反应评估。定量MRI生物标志物支持个性化治疗策略和改善子宫癌患者管理。
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来源期刊
Insights into Imaging
Insights into Imaging Medicine-Radiology, Nuclear Medicine and Imaging
CiteScore
7.30
自引率
4.30%
发文量
182
审稿时长
13 weeks
期刊介绍: Insights into Imaging (I³) is a peer-reviewed open access journal published under the brand SpringerOpen. All content published in the journal is freely available online to anyone, anywhere! I³ continuously updates scientific knowledge and progress in best-practice standards in radiology through the publication of original articles and state-of-the-art reviews and opinions, along with recommendations and statements from the leading radiological societies in Europe. Founded by the European Society of Radiology (ESR), I³ creates a platform for educational material, guidelines and recommendations, and a forum for topics of controversy. A balanced combination of review articles, original papers, short communications from European radiological congresses and information on society matters makes I³ an indispensable source for current information in this field. I³ is owned by the ESR, however authors retain copyright to their article according to the Creative Commons Attribution License (see Copyright and License Agreement). All articles can be read, redistributed and reused for free, as long as the author of the original work is cited properly. The open access fees (article-processing charges) for this journal are kindly sponsored by ESR for all Members. The journal went open access in 2012, which means that all articles published since then are freely available online.
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