Genome-wide analysis of genetic loci and candidate genes related to teat number traits in Dongliao black pigs.

IF 2.8 3区生物学 Q2 GENETICS & HEREDITY

Frontiers in Genetics Pub Date : 2025-05-14 eCollection Date: 2025-01-01 DOI:10.3389/fgene.2025.1593395

Juan Ke, Changyi Chen, Junwen Fei, Ke Luo, Yu Cheng, Huimin Yu, Chao Cheng, Yiqing Yan, Xiaoran Zhang, Shuang Liang, Hao Sun, Chunyan Bai, Boxing Sun

引用次数: 0

Abstract

This study investigated the genetic basis of teat number variation in Dongliao black pigs. A total of 765 pigs were genotyped using the Porcine 50K SNP chip, and their teat numbers were recorded. Heritability estimates for total teat number (TTN) and teat pair number (TPN) were 0.091 and 0.097, respectively. Genome-wide association studies identified 74 significant SNPs for TTN and 105 for TPN. Nine candidate genes related to the teat number were identified: CSNK1G1, PLEKHM2, CABLES1, SLC25A21, RYR3, PIGH, GUCY1A1, RAPGEF2, and TRPC4AP. These findings provide insights into the genetic architecture of teat number variation in Dongliao black pigs.

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东辽黑猪乳头数性状相关基因位点及候选基因的全基因组分析。

研究了东辽黑猪乳头数变异的遗传基础。使用猪50K SNP芯片对765头猪进行基因分型，并记录其乳头数。总乳头数（TTN）和乳头对数（TPN）的遗传力分别为0.091和0.097。全基因组关联研究发现TTN有74个显著snp， TPN有105个显著snp。共鉴定出9个与乳头数相关的候选基因：CSNK1G1、PLEKHM2、CABLES1、SLC25A21、RYR3、PIGH、GUCY1A1、RAPGEF2和TRPC4AP。这些发现为研究东辽黑猪乳头数变异的遗传结构提供了新的思路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Genetics Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

5.50

自引率

8.10%

发文量

3491

审稿时长

14 weeks

期刊介绍： Frontiers in Genetics publishes rigorously peer-reviewed research on genes and genomes relating to all the domains of life, from humans to plants to livestock and other model organisms. Led by an outstanding Editorial Board of the world’s leading experts, this multidisciplinary, open-access journal is at the forefront of communicating cutting-edge research to researchers, academics, clinicians, policy makers and the public. The study of inheritance and the impact of the genome on various biological processes is well documented. However, the majority of discoveries are still to come. A new era is seeing major developments in the function and variability of the genome, the use of genetic and genomic tools and the analysis of the genetic basis of various biological phenomena.