AgRP1 modulates breeding season-dependent feeding behavior in female medaka.

IF 6.4 1区 生物学 Q1 BIOLOGY
eLife Pub Date : 2025-05-29 DOI:10.7554/eLife.100996
Yurika Tagui, Shingo Takeda, Hiroyo Waida, Shoichi Kitahara, Tomoki Kimura, Shinji Kanda, Yoshitaka Oka, Yu Hayashi, Chie Umatani
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Abstract

Feeding and reproduction are known to be closely correlated with each other, and the seasonal breeders show breeding season-dependent feeding behavior. However, most model animals do not have definite breeding seasonality, and the mechanisms for such feeding behavior remain unclear. Here, we focused on female medaka (Oryzias latipes); they show breeding season-dependent feeding behavior, and their condition of breeding season can be experimentally controlled by day-length. We first demonstrated that, among previously reported feeding-related peptides (neuropeptides involved in feeding), agouti-related peptide 1 (agrp1) and neuropeptide y b (npyb) show higher brain expression under the breeding condition than under the non-breeding one. Combined with analysis of agrp1 knockout medaka, we obtained results to suggest that long day-induced sexually mature condition, especially ovarian estrogenic signals, increase the expressions of agrp1 in the brain, which results in increased food intake to promote reproduction. Our findings advance the understanding of neural mechanisms of feeding behavior for reproductive success.

agp1调节雌性medaka的繁殖季节依赖性摄食行为。
饲养与繁殖密切相关,季节性繁殖者表现出随繁殖季节而变化的饲养行为。然而,大多数模式动物没有明确的繁殖季节,这种摄食行为的机制尚不清楚。在这里,我们关注的是雌性medaka (Oryzias latipes);它们的取食行为随繁殖季节而变化,繁殖季节的条件可以通过日长来控制。我们首先证明,在先前报道的饲养相关肽(参与饲养的神经肽)中,在繁殖条件下,鼠腿相关肽1 (agrp1)和神经肽yb (npyb)在大脑中的表达高于非繁殖条件。结合对agrp1基因敲除medaka的分析,我们得到的结果表明,长白天诱导的性成熟状态,特别是卵巢雌激素信号,增加了大脑中agrp1的表达,从而导致食物摄入量增加,从而促进生殖。我们的发现促进了对繁殖成功的摄食行为的神经机制的理解。
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来源期刊
eLife
eLife BIOLOGY-
CiteScore
12.90
自引率
3.90%
发文量
3122
审稿时长
17 weeks
期刊介绍: eLife is a distinguished, not-for-profit, peer-reviewed open access scientific journal that specializes in the fields of biomedical and life sciences. eLife is known for its selective publication process, which includes a variety of article types such as: Research Articles: Detailed reports of original research findings. Short Reports: Concise presentations of significant findings that do not warrant a full-length research article. Tools and Resources: Descriptions of new tools, technologies, or resources that facilitate scientific research. Research Advances: Brief reports on significant scientific advancements that have immediate implications for the field. Scientific Correspondence: Short communications that comment on or provide additional information related to published articles. Review Articles: Comprehensive overviews of a specific topic or field within the life sciences.
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