Pyogenic liver abscess following biliary stent placement in pancreatic cancer patients: a retrospective case series.

IF 3.4 2区 医学 Q2 ONCOLOGY
Dongxue Geng, Nan Lv, Yi Miao
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引用次数: 0

Abstract

Biliary stent placement is widely used in clinical, especially in patients with pancreatic cancer complicated with obstructive jaundice. Pyogenic liver abscess (PLA) is a severe complication following biliary stent placement which predominantly occurs in the right lobe of the liver, with an incidence rate ranging from 4.3% to 13.5% and a mortality rate up to 30%. It is related to the following mechanisms: retrograde bacterial infection; bile stasis and increased bile duct pH; stent-related bile duct injury; biofilm formation; immune system suppression. The main causative pathogens are gram-negative bacilli, particularly Escherichia coli and Klebsiella pneumoniae. The combination of antibiotic therapy and percutaneous transhepatic abscess drainage is the main treatment option.

胰腺癌患者胆道支架置入术后化脓性肝脓肿:回顾性病例系列。
胆道支架置入术在临床上被广泛应用,尤其是在胰腺癌合并梗阻性黄疸的患者中。化脓性肝脓肿(PLA)是胆道支架置入术后的严重并发症,主要发生在肝右叶,发病率为4.3% ~ 13.5%,死亡率高达30%。它与以下机制有关:逆行性细菌感染;胆汁淤积和胆管pH值升高;支架相关性胆管损伤;生物膜的形成;免疫系统抑制。主要致病菌为革兰氏阴性杆菌,尤其是大肠杆菌和肺炎克雷伯菌。抗生素联合经皮肝脓肿引流是主要的治疗方案。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
BMC Cancer
BMC Cancer 医学-肿瘤学
CiteScore
6.00
自引率
2.60%
发文量
1204
审稿时长
6.8 months
期刊介绍: BMC Cancer is an open access, peer-reviewed journal that considers articles on all aspects of cancer research, including the pathophysiology, prevention, diagnosis and treatment of cancers. The journal welcomes submissions concerning molecular and cellular biology, genetics, epidemiology, and clinical trials.
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