Association of the IL-6R rs2228145 polymorphism with diabetic nephropathy: A case-control study

IF 3 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Journal of Diabetes Investigation Pub Date : 2025-05-29 DOI:10.1111/jdi.70073

Pavla Izakovicova, Simona Slezakova, Tereza Deissova, Hana Poskerova, Petra Borilova Linhartova, Ladislav Dusek, Katerina Kankova, Lydie Izakovicova Holla

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引用次数: 0

Abstract

Introduction

The pathogenesis of diabetes mellitus (DM) and its complications has been previously linked to elevated levels of interleukin-6 (IL-6); IL-6 triggers intracellular pathways through interaction with the IL-6 receptor (IL-6R). This study aimed to determine the association of single nucleotide polymorphisms (SNPs) IL-6 −597G/A (rs1800797), −572G/C (rs1800796), −174G/C (rs1800795), its receptor (IL-6R) Asp358Ala (+48892A/C, rs2228145) and DM or its complications in the Czech population.

Materials and Methods

In total, 669 subjects participated in this case-control study, including 167 controls, 119 patients with type 1 DM (T1DM), and 383 patients with type 2 DM (T2DM). The subjects were monitored for glycemia, glycated hemoglobin, lipid profile, glomerular filtration rate (GFR), and common complications, such as diabetic nephropathy (DN), retinopathy (DR), (poly)neuropathy (DPN), and periodontitis (P).

Results

Frequencies of the IL-6 and IL-6R alleles or genotypes, and IL-6 haplotypes were similar between the controls and the patients with T1DM or T2DM (P > 0.05). However, lower values of GFR were observed in diabetic patients with IL-6 −174CC homozygotes compared to other (CG and GG) genotypes (P ≤ 0.05). In addition, the IL-6R Asp358Ala variant was associated with DN (P = 0.031, OR = 1.74, 95% CI: 1.05–2.89). After subclassification according to the type of DM, the significant association of the IL-6R polymorphism with DN was only found in T1DM (P = 0.013, OR = 2.90, 95% CI: 1.25–6.71).

Conclusions

This study implies a significant relationship between the IL-6R Asp358Ala polymorphism and DN in Czech T1DM patients.

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IL-6R rs2228145多态性与糖尿病肾病的关系：一项病例对照研究

导论：糖尿病（DM）及其并发症的发病机制与白细胞介素-6 （IL-6）水平升高有关；IL-6通过与IL-6受体（IL-6R）相互作用触发细胞内通路。本研究旨在确定捷克人群中单核苷酸多态性（snp） IL-6 -597G/A （rs1800797）、-572G/C （rs1800796）、-174G/C （rs1800795）及其受体（IL-6R） Asp358Ala （+48892A/C, rs2228145）与DM或其并发症的关系。材料与方法：共纳入病例对照研究669例，其中对照组167例，1型糖尿病（T1DM）患者119例，2型糖尿病（T2DM）患者383例。监测受试者的血糖、糖化血红蛋白、血脂、肾小球滤过率（GFR）和常见并发症，如糖尿病肾病（DN）、视网膜病变（DR）、（多）神经病变（DPN）和牙周炎(P)。结果：对照组与T2DM、T1DM患者IL-6、IL-6R等位基因或基因型、IL-6单倍型频率相似（P < 0.05）。而IL-6 -174CC纯合子的糖尿病患者GFR值低于其他基因型（CG和GG）（P≤0.05）。此外，IL-6R Asp358Ala变异与DN相关（P = 0.031, OR = 1.74, 95% CI: 1.05-2.89）。根据DM的类型细分后，IL-6R多态性与DN的显著相关性仅在T1DM中发现（P = 0.013, OR = 2.90, 95% CI: 1.25 ~ 6.71）。结论：本研究提示捷克T1DM患者IL-6R Asp358Ala多态性与DN有显著关系。

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来源期刊

Journal of Diabetes Investigation ENDOCRINOLOGY & METABOLISM-

CiteScore

6.50

自引率

9.40%

发文量

218

审稿时长

6-12 weeks

期刊介绍： Journal of Diabetes Investigation is your core diabetes journal from Asia; the official journal of the Asian Association for the Study of Diabetes (AASD). The journal publishes original research, country reports, commentaries, reviews, mini-reviews, case reports, letters, as well as editorials and news. Embracing clinical and experimental research in diabetes and related areas, the Journal of Diabetes Investigation includes aspects of prevention, treatment, as well as molecular aspects and pathophysiology. Translational research focused on the exchange of ideas between clinicians and researchers is also welcome. Journal of Diabetes Investigation is indexed by Science Citation Index Expanded (SCIE).