Reactive Oxygen Species (ROS) and Their Profound Influence on Regulating Diverse Aspects of Cancer: A Concise Review

IF 4.2 4区 医学 Q2 CHEMISTRY, MEDICINAL
Rachana Tiwari, Ysani Mondal, Khyathi Bharadwaj, Mohita Mahajan, Sukanta Mondal, Angshuman Sarkar
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引用次数: 0

Abstract

Reactive oxygen species (ROS) produced during cellular metabolism impacts normal cell functions, including signaling, hormone regulation, growth factors, ion transport, and apoptosis. Cells regulate ROS levels by using antioxidant enzymes and nonenzymatic detoxifying agents to avoid damage. It is important to focus on ROS and its involvement in cancer biology, particularly tumor progression and metastasis. Focus has been given to the involvement of ROS in various signaling cascades and its effect on various transcription factors that modulate cancer metastasis and tumorigenesis. For metastatic colonization to occur, endothelial cells must grow and migrate within pre-existing blood vessels, a process known as angiogenesis. The process benefits cancerous cells by providing them with oxygen and nutrients. Therefore, we have summarized the work carried out in this field too. We have further discussed how ROS triggers apoptosis, necroptosis, and ferroptosis, which are examples of regulated cell death (RCD) mechanisms that can demonstrate antitumor effects when they accumulate beyond a certain point. ROS are crucial to regulating and initiating apoptosis in cancerous cells, which affects the cell's ability to increase, survive, and respond to treatments. We have compiled work on integrated bioinformatics analysis to understand the involvement of ROS in cancer biology. We conclude through this review that ROS has a complex role in cancer biology, acting as promoters and tumorigenesis suppressors. Future research will likely focus on harnessing ROS's dual nature for therapeutic benefit while minimizing its harmful effects on normal cells.

活性氧(ROS)及其在调节癌症各方面的深远影响:简要综述
细胞代谢过程中产生的活性氧(ROS)影响正常细胞功能,包括信号传导、激素调节、生长因子、离子转运和细胞凋亡。细胞通过使用抗氧化酶和非酶解毒剂来调节ROS水平以避免损伤。关注ROS及其在癌症生物学,特别是肿瘤进展和转移中的作用是很重要的。重点是ROS参与各种信号级联反应及其对调节癌症转移和肿瘤发生的各种转录因子的影响。为了发生转移性定植,内皮细胞必须在已有的血管中生长和迁移,这一过程被称为血管生成。这个过程通过为癌细胞提供氧气和营养物质而有益于癌细胞。因此,我们也对这一领域所开展的工作进行了总结。我们进一步讨论了ROS如何触发细胞凋亡、坏死坏死和铁下垂,这是调节细胞死亡(RCD)机制的例子,当它们积累超过某一点时,可以显示出抗肿瘤作用。活性氧是调节和启动癌细胞凋亡的关键,影响细胞的增殖、存活和对治疗的反应。我们汇编了综合生物信息学分析的工作,以了解活性氧在癌症生物学中的作用。我们通过这篇综述得出结论,ROS在癌症生物学中具有复杂的作用,可以作为肿瘤发生的启动子和抑制子。未来的研究可能会集中在利用活性氧的双重性质来获得治疗效益,同时最大限度地减少其对正常细胞的有害影响。
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来源期刊
CiteScore
6.40
自引率
2.60%
发文量
104
审稿时长
6-12 weeks
期刊介绍: Drug Development Research focuses on research topics related to the discovery and development of new therapeutic entities. The journal publishes original research articles on medicinal chemistry, pharmacology, biotechnology and biopharmaceuticals, toxicology, and drug delivery, formulation, and pharmacokinetics. The journal welcomes manuscripts on new compounds and technologies in all areas focused on human therapeutics, as well as global management, health care policy, and regulatory issues involving the drug discovery and development process. In addition to full-length articles, Drug Development Research publishes Brief Reports on important and timely new research findings, as well as in-depth review articles. The journal also features periodic special thematic issues devoted to specific compound classes, new technologies, and broad aspects of drug discovery and development.
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