Comparison of gait parameters and chronic lower body pain in people with multiple sclerosis

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2025-05-23 DOI:10.1016/j.msard.2025.106526

Abbas Tabatabaei , Tobia Zanotto , Libak Abou , Sharon G Lynch , Jacob Sosnoff

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引用次数: 0

Abstract

Background

Gait abnormalities are common in people with Multiple Sclerosis (pwMS). The relation between chronic pain in the lower body (CPLB) and gait impairment in Multiple Sclerosis is not clear.

Objective

To compare gait parameters between pwMS with and without CPLB. Methods: Forty pwMS (aged 54.3 y ± 7.7, 82.5 % women) took part in this crosssectional investigation. The revised Michigan Body Map was used to determine if the participants had CPLB. Participants were allocated to groups based on the presence of chronic pain in the lower body. Participants completed a standardized walk over a pressure-sensitive walkway (8 m), which was used to evaluate spatiotemporal gait parameters.

Results

Twenty-three and 17 pwMS were classified as having or not having CPLB, respectively. Participants with CPLB exhibited significantly slower gait speed (cm/s) (p = 0.01, mean difference (MD) 27.64 [95 % CI: 5.8 to 49.4]), fewer number of steps (p = 0.01, MD 14.20 [95 % CI: 2.90 to 25.50]), shorter steps (p = 0.04, MD 7 95 % CI: 14.2 to 25.5), prolonged steps (s) (p = 0.02, MD -0.11 [95 % CI:0.20 to -0.01]), lower percentage (p = 0.01, MD 2.70 [95 % CI: 0.50 to 4.9]) and higher variability (p = 0.01, MD 12.5 [95 % CI: 52.6 to 6.7]) of single-leg support (SLS) time compared to those without CPLB. The observed difference in gait speed exceeded the minimal clinically important differences.

Conclusion

This study revealed alterations in gait among pwMS with CPLB compared to those without pain. These findings can be leveraged in future studies to develop targeted rehabilitation strategies that focus on chronic pain in the lower body and gait.

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多发性硬化症患者步态参数与慢性下半身疼痛的比较

步态异常在多发性硬化症（pwMS）患者中很常见。多发性硬化症患者下肢慢性疼痛（CPLB）与步态障碍之间的关系尚不清楚。目的比较带CPLB和不带CPLB的pwMS的步态参数。方法：40例pwMS （54.3 y±7.7,82.5%为女性）参与横断面调查。修订后的密歇根身体图用于确定参与者是否患有CPLB。参与者根据下半身慢性疼痛的情况被分配到不同的小组。参与者在压力敏感通道（8米）上完成标准化步行，用于评估时空步态参数。结果23例有CPLB， 17例无CPLB。参与者CPLB表现出明显慢步态速度(cm / s) (p = 0.01,平均差(MD) 27.64(95%置信区间CI: 5.8 - 49.4)),更少的步骤(马里兰州p = 0.01 14.20(95%置信区间CI: 2.90 - 25.50)),较短的步骤(p = 0.04, MD 7 95%置信区间:14.2 - 25.5),长时间的步骤(s) (p = 0.02, MD -0.11(95%置信区间CI: 0.20 - -0.01)),较低的百分比(p = 0.01, MD 2.70(95%置信区间CI: 0.50 - 4.9))和更高的可变性(马里兰州p = 0.01 12.5(95%置信区间CI:与没有CPLB的患者相比，单腿支持（SLS）时间增加了52.6至6.7]。观察到的步态速度差异超过了最小的临床重要差异。结论：与无疼痛的pwMS相比，该研究揭示了伴有CPLB的pwMS患者步态的改变。这些发现可以在未来的研究中加以利用，以制定有针对性的康复策略，重点关注下半身和步态的慢性疼痛。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.