Advances towards gastric cancer screening: Novel devices and biomarkers

IF 3.2 3区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Best Practice & Research Clinical Gastroenterology Pub Date : 2025-03-01 DOI:10.1016/j.bpg.2025.102009

Catarina Lopes , Carina Pereira

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Abstract

Gastric cancer is a pressing global health issue that ranks fifth as the most commonly diagnosed malignancy and leading cause of cancer-related deaths. Early detection is critical for improving patient outcomes, with five-year survival rates exceeding 90 % when diagnosed at initial stages. Current screening modalities, primarily reliant on upper gastrointestinal endoscopy, are highly accurate, but not without limitations, such as invasiveness, high cost, low adherence and accessibility.

Hence, this review aligns with the ongoing efforts to answer the pressing need for innovative approaches, emphasising novel devices and biomarker advancements over the last decade. We highlight non-endoscopic methods such as magnetically controlled capsule endoscopy and point-of-care testing. Additionally, we will provide an overview into the field of liquid biopsies and emerging biomarkers in GC detection, towards accurate, less invasive and costly screening tools that hold the promise for greater accessibility and citizen involvement.

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胃癌筛查的新进展：新设备和生物标志物

胃癌是一个紧迫的全球健康问题，排名第五，是最常见的恶性肿瘤，也是癌症相关死亡的主要原因。早期发现对于改善患者预后至关重要，在初始阶段得到诊断的5年生存率超过90%。目前的筛查方式，主要依赖于上消化道内窥镜，是高度准确的，但并非没有限制，如侵入性，高成本，低依从性和可及性。因此，这篇综述与正在进行的努力相一致，以回答对创新方法的迫切需求，强调在过去十年中新设备和生物标志物的进步。我们强调非内窥镜方法，如磁控胶囊内窥镜和即时检测。此外，我们将概述气相色谱检测中的液体活检和新兴生物标志物领域，以实现准确，侵入性低，成本高的筛选工具，这些工具有望提高可及性和公民参与度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Best Practice & Research Clinical Gastroenterology 医学-胃肠肝病学

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

69 days

期刊介绍： Each topic-based issue of Best Practice & Research Clinical Gastroenterology will provide a comprehensive review of current clinical practice and thinking within the specialty of gastroenterology.