[Chinese expert consensus on screening and clinical application of monoclonal immunoglobulins(2025)].

Abstract

Monoclonal immunoglobulins (M proteins) are homogeneous immunoglobulins or their fragments (such as light chains) secreted by clonal B cells or plasma cells. M protein-related diseases are a group of disorders characterized by the presence of M proteins in the blood and/or urine. M protein screening helps in early M protein-related disease detection. To enhance the early detection of M protein-related diseases, domestic hematologists have developed this consensus, which systematically introduces the current screening methods for M proteins and their clinical application scenarios to guide clinical practice.