Association of Body Composition Parameters with Aortic Elastic Properties in newly diagnosed type 2 diabetics.

IF 0.8 Q2 MEDICINE, GENERAL & INTERNAL
Turgut Karabag, Işil Isel, Sena Hekimoglu Ustabas, Şebnem Javadova, Özgür Can Usta, Onurcan Turk, Ahmet Oz, M Sait Altintas
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引用次数: 0

Abstract

Background: In individuals with type 2 diabetes mellitus (T2DM), impairments in aortic elastic functions due to vascular remodeling and changes in cardiac morphology and function are observed from the time of diagnosis.

Objective: This study investigated alterations in aortic elastic functions in newly diagnosed T2DM patients using transthoracic echocardiography (TTE) and explored their association with various body composition parameters.

Materials and methods: A total of 273 newly diagnosed diabetic patients (144 females; mean age: 50.7±12.2 years) and 139 control subjects without any detected diseases (90 females; mean age: 47.1±8.5 years) were included in the study. Echocardiographic parameters and aortic elastic properties were evaluated using TTE. Body composition indices, including Body Mass Index, Waist-to-Hip Ratio, Tri-Ponderal Mass Index (TMI), Visceral Adiposity Index, Body Shape Index, Body Roundness Index, Body Adiposity Index, and Cardiometabolic Index were calculated for all participants.

Results: When aortic elastic parameters were evaluated, aortic strain and aortic distensibility were significantly lower in Group 1 compared to Group 2, while the aortic stiffness index was significantly higher in Group 1. Aortic elastic parameters were significantly correlated with most of all body composition indices except for BSI, with the highest correlation observed with TMI (AS; rho=0.490, ASI; rho=0.456, AD; 0.516; p<0.001).

Conclusion: In newly diagnosed T2DM patients, aortic elastic functions are impaired at the time of diagnosis compared to the normal population. Among body composition indices; the most significant association was found with TMI. TMI may be considered a potential screening tool not only for evaluating aortic elastic functions but also for identifying other atherosclerotic processes.

新诊断的2型糖尿病患者身体成分参数与主动脉弹性特性的关系
背景:在2型糖尿病(T2DM)患者中,从诊断时起就观察到血管重构引起的主动脉弹性功能损伤和心脏形态和功能的改变。目的:利用经胸超声心动图(TTE)研究新诊断T2DM患者主动脉弹性功能的改变,并探讨其与各种身体成分参数的关系。材料与方法:新诊断糖尿病患者273例(女性144例;平均年龄:50.7±12.2岁),未检出疾病的对照组139例(女性90例;平均年龄:47.1±8.5岁)。超声心动图参数和主动脉弹性性能评价采用TTE。计算所有参与者的身体组成指数,包括身体质量指数、腰臀比、三脑质量指数(TMI)、内脏脂肪指数、体型指数、身体圆度指数、身体脂肪指数和心脏代谢指数。结果:在评估主动脉弹性参数时,实验组1的主动脉应变和主动脉扩张性明显低于对照组2,而实验组1的主动脉硬度指数明显高于对照组2。主动脉弹性参数与除BSI外的大部分体成分指标均显著相关,其中与TMI (AS;ASIρ= 0.490;ρ= 0.456,广告;0.516;结论:与正常人群相比,新诊断T2DM患者在诊断时主动脉弹性功能受损。体成分指标;与TMI的关联最为显著。TMI可能被认为是一种潜在的筛选工具,不仅用于评估主动脉弹性功能,而且用于识别其他动脉粥样硬化过程。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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