Dry Eye Disease: From Causes to Patient Care and Clinical Collaboration-A Narrative Review.

IF 3.2 3区医学 Q2 OPHTHALMOLOGY

Ophthalmology and Therapy Pub Date : 2025-07-01 Epub Date: 2025-05-28 DOI:10.1007/s40123-025-01161-8

Pasquale Aragona, Stefano Barabino, Antonio Di Zazzo, Giuseppe Giannaccare, Edoardo Villani, Francesco Aiello, Elena Antoniazzi, Stefano Bonini, Emilia Cantera, Gianpaolo Carlini, Chiara Chierego, Rossella Colabelli, Romina Fasciani, Antonella Franch, Giovanna Gabbriellini, Caterina Maria Rita Gagliano, Andrea Leonardi, Angelo Macrì, Rita Mencucci, Luigi Mosca, Vincenzo Orfeo, Antonio Pinna, Augusto Pocobelli, Romolo Protti, Paolo Rama, Laura Rania, Miguel Rechichi, Pierangela Rubino, Andrea Russo, Vincenzo Scorcia, Leopoldo Spadea, Marco Trentadue, Salvatore Troisi, Piera Versura, Maurizio Rolando

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Abstract

Dry eye disease (DED) is a common condition of the ocular surface that affects tens of millions of people worldwide. It is often characterized by decreased tear production or increased evaporation, resulting in a wide range of signs and symptoms. This review provides a comprehensive analysis of the literature related to DED, detailing causes, diagnostic tests, and medical management. Several mechanisms contribute to the maintenance of the physiological integrity of the ocular surface, and their dysfunction may result in noticeable symptoms. Accurate diagnosis is therefore essential, even when physiological function is only minimally impaired or no clear pathological signs are present. The review emphasizes the importance of addressing the underlying causes through a combination of treatment options, lifestyle changes, and enhanced communication between patients and healthcare providers to break the cycle of inflammation and tear instability. It aims to raise awareness among patients, healthcare professionals, and researchers regarding the diagnosis and treatment of DED, while also highlighting recent advancements and future challenges in its management.

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干眼病：从病因到患者护理和临床合作的综述。

干眼病（DED）是一种常见的眼表疾病，影响着全世界数千万人。它通常以泪液产生减少或蒸发增加为特征，导致广泛的体征和症状。本文综述了与DED相关的文献，详细介绍了病因、诊断测试和医疗管理。几种机制有助于维持眼表的生理完整性，它们的功能障碍可能导致明显的症状。因此，准确的诊断是必不可少的，即使生理功能只有轻微受损或没有明显的病理症状。该综述强调了通过结合治疗方案、改变生活方式以及加强患者和医疗保健提供者之间的沟通来解决潜在原因的重要性，以打破炎症和撕裂不稳定的循环。它旨在提高患者、医疗保健专业人员和研究人员对DED的诊断和治疗的认识，同时也强调了其管理方面的最新进展和未来挑战。

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来源期刊

Ophthalmology and Therapy OPHTHALMOLOGY-

CiteScore

4.20

自引率

3.00%

发文量

157

审稿时长

6 weeks

期刊介绍： Aims and Scope Ophthalmology and Therapy is an international, open access, peer-reviewed (single-blind), and rapid publication journal. The scope of the journal is broad and will consider all scientifically sound research from preclinical, clinical (all phases), observational, real-world, and health outcomes research around the use of ophthalmological therapies, devices, and surgical techniques. The journal is of interest to a broad audience of pharmaceutical and healthcare professionals and publishes original research, reviews, case reports/series, trial protocols and short communications such as commentaries and editorials. Ophthalmology and Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of quality research, which may be considered of insufficient interest by other journals. Rapid Publication The journal’s publication timelines aim for a rapid peer review of 2 weeks. If an article is accepted it will be published 3–4 weeks from acceptance. The rapid timelines are achieved through the combination of a dedicated in-house editorial team, who manage article workflow, and an extensive Editorial and Advisory Board who assist with peer review. This allows the journal to support the rapid dissemination of research, whilst still providing robust peer review. Combined with the journal’s open access model this allows for the rapid, efficient communication of the latest research and reviews, fostering the advancement of ophthalmic therapies. Open Access All articles published by Ophthalmology and Therapy are open access. Personal Service The journal’s dedicated in-house editorial team offer a personal “concierge service” meaning authors will always have an editorial contact able to update them on the status of their manuscript. The editorial team check all manuscripts to ensure that articles conform to the most recent COPE, GPP and ICMJE publishing guidelines. This supports the publication of ethically sound and transparent research. Digital Features and Plain Language Summaries Ophthalmology and Therapy offers a range of additional features designed to increase the visibility, readership and educational value of the journal’s content. Each article is accompanied by key summary points, giving a time-efficient overview of the content to a wide readership. Articles may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand the scientific content and overall implications of the article. The journal also provides the option to include various types of digital features including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations. All additional features are peer reviewed to the same high standard as the article itself. If you consider that your paper would benefit from the inclusion of a digital feature, please let us know. Our editorial team are able to create high-quality slide decks and infographics in-house, and video abstracts through our partner Research Square, and would be happy to assist in any way we can. For further information about digital features, please contact the journal editor (see ‘Contact the Journal’ for email address), and see the ‘Guidelines for digital features and plain language summaries’ document under ‘Submission guidelines’. 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