It’s in the blood: plasma as a source for biochemical identification and biological characterization of novel leukocyte chemoattractants.

IF 1.2 4区 医学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY
Jo Van Damme, Stijn Van Damme, Sofie Struyf, Ghislain Opdenakker
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引用次数: 0

Abstract

Since their discovery, chemotactic cytokines or chemokines have been intensively studied for about half a century. Chemokines originate from tissue cells, leukocytes, blood platelets and plasma. Here, we review a number of seminal findings on plasma chemokines within an historical and international context. These aspects include how induction and purification protocols led to the discovery of a new family of mediators, named chemokines, on the basis of protein sequencing; how molecular cloning techniques facilitated discoveries of additional family members on the basis of conserved protein structures; how blood plasma and platelets were used as a source of inducible and constitutively expressed chemokines; how various forms of proteolytic reactions may convert precursor proteins into chemokines and either potentiate or inactivate their activity; how abundancy classes and synergism should be interpreted through critically considering plasma chemokine biology; and how other blood proteins, such as serum amyloid A, interact in functional terms with CXC and CC chemokines. The gradual dissection of all these elements not only reveals the complexity of chemokine actions, but also stimulates a more comprehensive interpretation of chemokine levels in plasma and serum, with future chemokinome analyses in mind.

它存在于血液:血浆中,作为新型白细胞化学引诱剂的生物化学鉴定和生物学特性的来源。
自从它们被发现以来,趋化细胞因子或趋化因子已经被深入研究了大约半个世纪。趋化因子来源于组织细胞、白细胞、血小板和血浆。在这里,我们回顾了历史和国际背景下血浆趋化因子的一些开创性发现。这些方面包括诱导和纯化方案如何导致在蛋白质测序的基础上发现新的介质家族,称为趋化因子;分子克隆技术如何在保守蛋白质结构的基础上促进发现其他家族成员;血浆和血小板如何被用作诱导和组成型表达趋化因子的来源;各种形式的蛋白水解反应如何将前体蛋白转化为趋化因子,并增强或灭活它们的活性;如何通过批判性地考虑血浆趋化因子生物学来解释丰度分类和协同作用;以及其他血液蛋白,如血清淀粉样蛋白A,如何在功能上与CXC和CC趋化因子相互作用。所有这些元素的逐渐解剖不仅揭示了趋化因子作用的复杂性,而且还刺激了对血浆和血清中趋化因子水平的更全面的解释,并考虑到未来的趋化因子组分析。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
European cytokine network
European cytokine network 生物-免疫学
CiteScore
5.70
自引率
0.00%
发文量
5
审稿时长
6 months
期刊介绍: The journal that brings together all areas of work involving cytokines. European Cytokine Network is an electronic journal that publishes original articles and abstracts every quarter to provide an essential bridge between researchers and clinicians with an interest in this cutting-edge field. The journal has become a must-read for specialists in the field thanks to its swift publication and international circulation. The journal is referenced in several databases, including Medline, which is testament to its scientific quality.
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