{"title":"Clear cell borderline tumour of the ovary: a rare entity.","authors":"Kaarthiga Ramalingam Gopinath, Chitra Thyagaraju, Bhawana Ashok Badhe","doi":"10.1136/bcr-2025-266082","DOIUrl":null,"url":null,"abstract":"<p><p>Borderline clear cell tumours of the ovary are exceedingly rare, with limited cases documented in literature. We present a case of a woman with primary infertility who presented with abnormal uterine bleeding and a history of bilateral endometriotic cysts. Abdominal examination revealed a mass of 17×12 cm. CT imaging showed a heterogeneous solid-cystic mass measuring 16.6×10.8 cm in the right adnexa with elevated cancer antigen 125 (CA-125) levels (761.9 IU/mL). Staging laparotomy was performed due to high suspicion of malignancy. Intraoperatively, a right ovarian mass of 18×14 cm size, with intact capsule, and a 3×3 cm left ovarian endometriotic cyst were found. Microscopically, the mass showed a multiloculated cyst wall lined by cuboidal epithelium, without significant nuclear atypia or stromal invasion, and was positive for Napsin A. The overall features were suggestive of clear cell borderline tumour. Postoperative CA-125 level was normalised and the patient was placed under regular follow-up.</p>","PeriodicalId":9080,"journal":{"name":"BMJ Case Reports","volume":"18 5","pages":""},"PeriodicalIF":0.6000,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMJ Case Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1136/bcr-2025-266082","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Borderline clear cell tumours of the ovary are exceedingly rare, with limited cases documented in literature. We present a case of a woman with primary infertility who presented with abnormal uterine bleeding and a history of bilateral endometriotic cysts. Abdominal examination revealed a mass of 17×12 cm. CT imaging showed a heterogeneous solid-cystic mass measuring 16.6×10.8 cm in the right adnexa with elevated cancer antigen 125 (CA-125) levels (761.9 IU/mL). Staging laparotomy was performed due to high suspicion of malignancy. Intraoperatively, a right ovarian mass of 18×14 cm size, with intact capsule, and a 3×3 cm left ovarian endometriotic cyst were found. Microscopically, the mass showed a multiloculated cyst wall lined by cuboidal epithelium, without significant nuclear atypia or stromal invasion, and was positive for Napsin A. The overall features were suggestive of clear cell borderline tumour. Postoperative CA-125 level was normalised and the patient was placed under regular follow-up.
期刊介绍:
BMJ Case Reports is an important educational resource offering a high volume of cases in all disciplines so that healthcare professionals, researchers and others can easily find clinically important information on common and rare conditions. All articles are peer reviewed and copy edited before publication. BMJ Case Reports is not an edition or supplement of the BMJ.