FDG-avid thyroid nodules are at a significantly increased risk of malignancy.

IF 2.7 3区医学 Q1 SURGERY

American journal of surgery Pub Date : 2025-05-08 DOI:10.1016/j.amjsurg.2025.116400

Brodie D Laurie, Elizabeth Thomas, Hieu Nguyen, Simon Ryan, David Leong

{"title":"FDG-avid thyroid nodules are at a significantly increased risk of malignancy.","authors":"Brodie D Laurie, Elizabeth Thomas, Hieu Nguyen, Simon Ryan, David Leong","doi":"10.1016/j.amjsurg.2025.116400","DOIUrl":null,"url":null,"abstract":"Background: FDG-avid thyroid incidentalomas pose a diagnostic challenge due to their potential for malignancy. This study evaluated the malignancy rates in FDG-avid thyroid nodules, stratified by fine needle aspiration (FNA) cytology results.Methods: A retrospective cohort study was conducted on patients with FDG-avid thyroid incidentalomas who underwent surgical resection between 2012 and 2023. The primary outcome was malignancy rates stratified by pre-operative cytology results. Logistic regression was used to assess the utility of patient age, gender and nodule size for predicting malignancy in FDG-avid thyroid incidentaloma.Results: Of 258 patients included, malignancy rates stratified by cytology were: Bethesda I (15.4 %), Bethesda II(11.1 %), Bethesda III(29.1 %), Bethesda IV(34 %), Bethesda V (83.3 %), and Bethesda VI (98.3 %). The overall malignancy rate was 48.1 %, predominantly papillary thyroid carcinoma. No significant differences in malignancy were observed concerning age, gender, or nodule size.Conclusion: FDG-avid thyroid nodules exhibit a significantly higher risk of malignancy, particularly in Bethesda categories III to VI.","PeriodicalId":7771,"journal":{"name":"American journal of surgery","volume":" ","pages":"116400"},"PeriodicalIF":2.7000,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American journal of surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.amjsurg.2025.116400","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: FDG-avid thyroid incidentalomas pose a diagnostic challenge due to their potential for malignancy. This study evaluated the malignancy rates in FDG-avid thyroid nodules, stratified by fine needle aspiration (FNA) cytology results.

Methods: A retrospective cohort study was conducted on patients with FDG-avid thyroid incidentalomas who underwent surgical resection between 2012 and 2023. The primary outcome was malignancy rates stratified by pre-operative cytology results. Logistic regression was used to assess the utility of patient age, gender and nodule size for predicting malignancy in FDG-avid thyroid incidentaloma.

Results: Of 258 patients included, malignancy rates stratified by cytology were: Bethesda I (15.4 %), Bethesda II(11.1 %), Bethesda III(29.1 %), Bethesda IV(34 %), Bethesda V (83.3 %), and Bethesda VI (98.3 %). The overall malignancy rate was 48.1 %, predominantly papillary thyroid carcinoma. No significant differences in malignancy were observed concerning age, gender, or nodule size.

Conclusion: FDG-avid thyroid nodules exhibit a significantly higher risk of malignancy, particularly in Bethesda categories III to VI.

查看原文本刊更多论文

fdg旺盛的甲状腺结节发生恶性肿瘤的风险显著增加。

背景：fdg -甲状腺偶发瘤由于其潜在的恶性肿瘤，给诊断带来了挑战。本研究通过细针穿刺（FNA）细胞学结果对fdg阳性甲状腺结节的恶性率进行了评估。方法：回顾性队列研究2012 - 2023年间行手术切除的fdg阳性甲状腺偶发瘤患者。主要结果是术前细胞学结果分层的恶性肿瘤发生率。采用Logistic回归来评估患者年龄、性别和结节大小在预测fdg型甲状腺偶发瘤恶性程度方面的效用。结果：258例患者中，按细胞学分层的恶性肿瘤发生率为：Bethesda I（15.4%）、Bethesda II（11.1%）、Bethesda III（29.1%）、Bethesda IV（34%）、Bethesda V（83.3%）和Bethesda VI（98.3%）。总恶性率为48.1%，以甲状腺乳头状癌为主。恶性肿瘤在年龄、性别或结节大小方面无显著差异。结论：fdg阳性甲状腺结节表现出明显更高的恶性风险，特别是在Bethesda III至VI类。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

American journal of surgery 医学-外科

CiteScore

5.00

自引率

6.70%

发文量

570

审稿时长

56 days

期刊介绍： The American Journal of Surgery® is a peer-reviewed journal designed for the general surgeon who performs abdominal, cancer, vascular, head and neck, breast, colorectal, and other forms of surgery. AJS is the official journal of 7 major surgical societies* and publishes their official papers as well as independently submitted clinical studies, editorials, reviews, brief reports, correspondence and book reviews.