Association of Markers of iron Metabolism with Mucormycosis: A Case Control Study.

IF 0.6 Q4 SURGERY

Indian Journal of Otolaryngology and Head and Neck Surgery Pub Date : 2025-06-01 Epub Date: 2025-05-05 DOI:10.1007/s12070-025-05506-4

Ankita Semwal, Amit Kumar Tyagi, Prasan Kumar Panda, Amit Kumar, Bhinyaram, Kalyani Sridharan, Bela Goyal, Ashok Kumar, Gaurav Dhingra, Sharon Kandari, Mahendra Singh

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引用次数: 0

Abstract

Aim and objective: To estimate the association of mucormycosis with markers of iron metabolism and to correlate levels of serum ferritin with stage of mucormycosis.

Materials and methods: We conducted a case control study in hundred (50 cases and 50 controls) patients. Biopsy proven mucormycosis patients were taken as cases. Controls were selected from the same study population as the cases, and they were representative of the population at risk. Controls were matched for the age, gender, and all known risk factors of mucormycosis, and for each case, one control was taken.

Result: We enrolled 50 cases and 50 controls. Rhino-orbital mucormycosis (50%) was the most encountered clinical presentation among cases followed by rhino-orbital-cerebral mucormycosis (36%). Diabetes mellitus was the most commonly encountered risk factor (96%). The mean serum iron (ug/dl) value (41.5 vs. 72, p < 0.001) and transferrin saturation (%) value (14.1 vs. 19.86, < 0.001) were significantly lower in cases than in controls. The mean serum ferritin (ng/ml) value (2087.6 vs. 174.5, < 0.001) was higher in cases as compared to controls.

Conclusion: Higher serum ferritin values seem to be an indicator of the severity of disease in the present study. Individuals with elevated serum ferritin levels must be carefully managed with anticipation of severe outcomes, especially in those who have concurrent risk factors.

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铁代谢标志物与毛霉病的关联：一项病例对照研究。

目的和目的：估计毛霉病与铁代谢标志物的关系，并将血清铁蛋白水平与毛霉病的分期相关联。材料和方法：我们对100例患者（50例患者和50例对照组）进行了病例对照研究。以活检证实的毛霉病患者为例。对照从与病例相同的研究人群中选择，他们是有风险人群的代表。对照者的年龄、性别和所有已知的毛霉病危险因素相匹配，每个病例采取一个对照。结果：我们纳入了50例病例和50例对照。鼻眶毛霉菌病（50%）是最常见的临床表现，其次是鼻眶脑毛霉菌病（36%）。糖尿病是最常见的危险因素（96%）。平均血清铁（ug/dl）值（41.5 vs. 72, p）结论：在本研究中，较高的血清铁蛋白值似乎是疾病严重程度的一个指标。血清铁蛋白水平升高的个体必须谨慎管理，预期严重后果，特别是那些同时存在危险因素的个体。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Indian Journal of Otolaryngology and Head and Neck Surgery Medicine-Otorhinolaryngology

CiteScore

0.80

自引率

0.00%

发文量

226

审稿时长

6-12 weeks

期刊介绍： Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress. IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc. The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world. The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members. Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.