A Rare Deep Neck Infection Associated with COVID: Etiology - Cytomegalovirus.

IF 0.6 Q4 SURGERY
Şeyda Akbal Çufalı, Kürşat Murat Özcan, Ayşe Seçil Kayalı Dinç, Ayşe Yasemin Tezer Tekçe, Ömer Faruk Çufalı, Abdulkerim Taşdemir
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引用次数: 0

Abstract

Deep neck infections can progress from the oral cavity and oropharynx to the posterior cervical region or mediastinum, often leading to life-threatening complications. These infections are primarily caused by bacterial pathogens, and treatment is usually directed against the bacteria and occasionally against the fungi. This article presents the cases of two geriatric patients with diabetes mellitus and a history of coronavirus disease 2019 (COVID-19). Both patients developed deep neck infections unresponsive to antibiotic and antifungal therapy with a unique progression pattern. Although they were negative for CMV IgM in blood tests, their CMV positivity was confirmed by tissue samples. After initiation of antiviral therapy, clinical improvement was achieved. Cytomegalovirus (CMV) should be considered as a potential causative agent of treatment-resistant deep neck infections, especially in patients with previous CMV exposure and immunosuppression. Tissue sampling and molecular diagnostics, such as CMV DNA PCR, play a crucial role in identifying rare pathogens when conventional tests are negative.

一种罕见的与COVID相关的深颈部感染:病因-巨细胞病毒。
深颈部感染可从口腔和口咽部发展到颈部后区或纵隔,常常导致危及生命的并发症。这些感染主要是由细菌病原体引起的,治疗通常针对细菌,偶尔针对真菌。本文报告2例老年糖尿病患者合并冠状病毒病(COVID-19)病史。两例患者均出现深颈部感染,对抗生素和抗真菌治疗无反应,具有独特的进展模式。虽然他们在血液测试中对巨细胞病毒IgM呈阴性,但组织样本证实了他们的巨细胞病毒阳性。开始抗病毒治疗后,临床得到改善。巨细胞病毒(CMV)应被认为是治疗抵抗性深颈部感染的潜在病原体,特别是在既往有巨细胞病毒暴露和免疫抑制的患者中。当常规检测呈阴性时,组织取样和分子诊断,如巨细胞病毒DNA PCR,在鉴定罕见病原体方面发挥了关键作用。
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来源期刊
CiteScore
0.80
自引率
0.00%
发文量
226
审稿时长
6-12 weeks
期刊介绍: Indian Journal of Otolaryngology and Head & Neck Surgery was founded as Indian Journal of Otolaryngology in 1949 as a scientific Journal published by the Association of Otolaryngologists of India and was later rechristened as IJOHNS to incorporate the changes and progress. IJOHNS, undoubtedly one of the oldest Journals in India, is the official publication of the Association of Otolaryngologists of India and is about to publish it is 67th Volume in 2015. The Journal published quarterly accepts articles in general Oto-Rhino-Laryngology and various subspecialities such as Otology, Rhinology, Laryngology and Phonosurgery, Neurotology, Head and Neck Surgery etc. The Journal acts as a window to showcase and project the clinical and research work done by Otolaryngologists community in India and around the world. It is a continued source of useful clinical information with peer review by eminent Otolaryngologists of repute in their respective fields. The Journal accepts articles pertaining to clinical reports, Clinical studies, Research articles in basic and applied Otolaryngology, short Communications, Clinical records reporting unusual presentations or lesions and new surgical techniques. The journal acts as a catalyst and mirrors the Indian Otolaryngologist’s active interests and pursuits. The Journal also invites articles from senior and experienced authors on interesting topics in Otolaryngology and allied sciences from all over the world. The print version is distributed free to about 4000 members of Association of Otolaryngologists of India and the e-Journal shortly going to make its appearance on the Springer Board can be accessed by all the members. Association of Otolaryngologists of India and M/s Springer India group have come together to co-publish IJOHNS from January 2007 and this bondage is going to provide an impetus to the Journal in terms of international presence and global exposure.
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