Spexin is a biomarker of the process that regulates leptin sensitivity

IF 2.8 4区医学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Peptides Pub Date : 2025-05-24 DOI:10.1016/j.peptides.2025.171416

Mohamed Badie Ahmed , Abdella M. Habib , Saif Badran , Abeer Alsherawi , Asma Syed , Hoda Khoogaly , Atalla Hammouda , Abdul-Badi Abou-Samra , Suhail A. Doi

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引用次数: 0

Abstract

The rising prevalence of obesity poses a critical threat to global health, prompting an urgent need for a comprehensive understanding of its underlying mechanisms. This study aimed to delve into the relationship between obesity, leptin sensitivity, and gut hormones, focusing on spexin, glucagon-like peptide-1 (GLP-1), and gastric inhibitory polypeptide (GIP). We examined patients undergoing body contouring surgeries to assess how these hormones and leptin interact. Blood samples were collected at three different time points, and hormone levels were analyzed. Our findings indicated that increases in GLP-1 and decreases in GIP correlated with improved leptin sensitivity, indicated by decreased plasma leptin levels and associated with increase in steepness of the plasma leptin-spexin slope. These results suggest that spexin may serve as a biomarker for leptin sensitivity, the latter influenced by gut hormones in obese individuals. The study provides further evidence that the modulation of leptin sensitivity by gut hormones could be key in addressing obesity and its metabolic consequences.

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Spexin是调节瘦素敏感性过程的生物标志物。

肥胖患病率的上升对全球健康构成了严重威胁，迫切需要全面了解其潜在机制。本研究旨在探讨肥胖、瘦素敏感性和肠道激素之间的关系，重点研究spexin、胰高血糖素样肽-1 （GLP-1）和胃抑制多肽（GIP）。我们检查了接受身体整形手术的患者，以评估这些激素和瘦素如何相互作用。在三个不同的时间点采集血样，并分析激素水平。我们的研究结果表明，GLP-1的增加和GIP的降低与瘦素敏感性的提高相关，这可以通过血浆瘦素水平的降低和血浆瘦素-spexin斜率的陡度增加来体现。这些结果表明，spexin可能作为瘦素敏感性的生物标志物，后者受肥胖个体肠道激素的影响。这项研究提供了进一步的证据，证明肠道激素对瘦素敏感性的调节可能是解决肥胖及其代谢后果的关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Peptides 医学-生化与分子生物学

CiteScore

6.40

自引率

6.70%

发文量

130

审稿时长

28 days

期刊介绍： Peptides is an international journal presenting original contributions on the biochemistry, physiology and pharmacology of biological active peptides, as well as their functions that relate to gastroenterology, endocrinology, and behavioral effects. Peptides emphasizes all aspects of high profile peptide research in mammals and non-mammalian vertebrates. Special consideration can be given to plants and invertebrates. Submission of articles with clinical relevance is particularly encouraged.