IL-6 and Olfactory Dysfunction: Focus on Changes, Effects, and Mechanisms.

IF 4.4 3区 医学 Q2 CELL BIOLOGY
Mediators of Inflammation Pub Date : 2025-05-19 eCollection Date: 2025-01-01 DOI:10.1155/mi/5891188
Xiao-Yu Song, Ya-Kui Mou, Han-Rui Wang, Yao Wang, Wan-Chen Liu, Ting Yang, Cai-Yu Sun, Chao Ren, Xi-Cheng Song
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引用次数: 0

Abstract

The sense of smell is vital for human life and risk identification. Many diseases can cause olfactory disorders, and early identification and intervention of olfactory disorders are crucial. Currently, the diagnosis of olfactory disorders in clinical practice mostly relies on subjective visual analog scale (VAS) evaluations, expensive and complex imaging, and neurophysiological examinations, which lead to poor patient compliance and low completion rates. Therefore, there is an urgent need to identify novel, objective, easily detectable biological indicators. Interleukin-6 (IL-6) is an inflammatory factor that is closely associated with olfactory dysfunction in various diseases. However, the role of IL-6 in the occurrence and development of olfactory disorders is not yet clear, which limits its clinical application. This article reviews the changes and possible mechanisms of IL-6 in various diseases associated with olfactory disorders, with the aim of providing a reference for the clinical application of IL-6 as a biomarker for olfactory disorders and promoting an in-depth exploration of its mechanism in the occurrence and development of olfactory disorders.

IL-6与嗅觉功能障碍:关注变化、影响和机制。
嗅觉对人类的生命和风险识别至关重要。许多疾病可引起嗅觉障碍,嗅觉障碍的早期识别和干预至关重要。目前,临床上对嗅觉障碍的诊断多依赖于主观视觉模拟量表(VAS)评估、昂贵复杂的影像学检查和神经生理检查,导致患者依从性差、完成率低。因此,迫切需要确定新的、客观的、易于检测的生物指标。白细胞介素-6 (IL-6)是一种炎症因子,与多种疾病的嗅觉功能障碍密切相关。然而,IL-6在嗅觉疾病发生发展中的作用尚不清楚,限制了其临床应用。本文就IL-6在嗅觉障碍相关疾病中的变化及可能的机制进行综述,旨在为IL-6作为嗅觉障碍生物标志物的临床应用提供参考,促进对其在嗅觉障碍发生发展中的机制的深入探索。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Mediators of Inflammation
Mediators of Inflammation 医学-免疫学
CiteScore
8.70
自引率
0.00%
发文量
202
审稿时长
4 months
期刊介绍: Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
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