Demonstration of an enhanced dosing pattern for debulking large and bulky unresectable tumors via differential hole-size spatially fractionated radiotherapy.

IF 2 4区 医学 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
Joshua Misa, William St Clair, Damodar Pokhrel
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引用次数: 0

Abstract

Purpose/objective: We propose a novel lattice deployment for spatially fractionated radiotherapy (SFRT) treatments. In this approach, a larger diameter high-dose sphere is centrally placed in the bulky tumor mass and surrounded by smaller diameter high-dose spheres.

Materials/methods: Thirty SFRT patients (10 head and neck [HN], 10 abdominal/pelvis, and 10 chest/lung cases) treated with an MLC-based crossfire method were retrospectively analyzed. Eleven differential hole-size lattice patterns were benchmarked against the clinically delivered SFRT plans (1 cm diameter cylinders, 2 cm spacing) and the standard uniform lattice pattern (1.5 cm diameter spheres, 3 cm spacing). These patterns varied in core diameter (C: 2-4 cm), spacing (S: 2-4 cm), and peripheral diameter (P: 1-2 cm). In addition to peak-to-valley-dose ratio (PVDR), tumor dose metrics (D50%, V50%, Dmean), Dmax to nearby critical organs, and ablative dose (V75%/V50% and V15Gy) were evaluated.

Results: 10 out of 11 differential hole-size patterns showed increases in D50%, Dmean, and V50% compared to the standard lattice pattern. One pattern (C = 3 cm, S = 2 cm, P = 1.5 cm) outperformed the clinical SFRT plans in D50% (Δ = 1.8 Gy, p = 0.003; Δ = 2.0 Gy, p = 0.015; Δ = 0.9 Gy, p = 0.045), Dmean (Δ = 1.6 Gy, p = 0.003; Δ = 1.7 Gy, p = 0.021; Δ = 0.7 Gy, p = 0.042), and V50% (Δ = 20.4%, p < 0.001; Δ = 16.6%, p = 0.008; Δ = 10.3%, p = 0.079) for the HN, abdominal/pelvis, and chest/lung SFRT patients, respectively. This pattern also demonstrated average increases to D5% D10%, D90% across all 30 patients compared to both benchmarked patterns. However, this pattern showed reduced PVDR compared to the clinical and standard SFRT plans but still achieved a ratio > 3.0. All differential hole-size patterns demonstrated decreases in Dmax to critical organs compared to the clinical SFRT plans. Moreover, compared to the clinical SFRT and the standard lattice plans, 9 out of 11 differential hole-size patterns demonstrated increases in V75%/V50% and V15Gy.

Conclusion: All differential hole-size SFRT replans were clinically acceptable, with C = 3 cm, S = 2 cm, and P = 1.5 cm providing the optimal setting for select tumors. Differential lattice patterns enhanced the ablative dose to the bulky tumors while restricting the maximum dose to adjacent critical organs.

通过不同孔大小的空间分割放射治疗,增强给药模式来减轻大而笨重的不可切除肿瘤。
目的/目的:我们提出了一种用于空间分割放疗(SFRT)治疗的新型点阵部署。在这种方法中,一个较大直径的高剂量球被放置在肿瘤肿块的中心,周围是较小直径的高剂量球。材料/方法:回顾性分析30例SFRT患者(头颈部[HN] 10例,腹部/骨盆10例,胸/肺10例)采用基于mlc的交叉火力法治疗。将11种不同孔径的晶格模式与临床交付的SFRT方案(直径为1 cm的圆柱体,间距为2 cm)和标准均匀晶格模式(直径为1.5 cm的球体,间距为3 cm)作为基准。这些模式在核心直径(C: 2-4 cm)、间距(S: 2-4 cm)和外周直径(P: 1-2 cm)上有所不同。除峰谷剂量比(PVDR)外,评估肿瘤剂量指标(D50%, V50%, Dmean),对附近关键器官的Dmax和消融剂量(V75%/V50%和V15Gy)。结果:与标准晶格模式相比,11种不同孔尺寸模式中有10种显示D50%, Dmean和V50%的增加。其中一种模式(C = 3 cm, S = 2 cm, P = 1.5 cm)的D50%优于临床SFRT计划(Δ = 1.8 Gy, P = 0.003;Δ = 2.0 Gy, p = 0.015;Δ= 0.9 Gy, p = 0.045), Dmean(Δ= 1.6 Gy, p = 0.003;Δ = 1.7 Gy, p = 0.021;Δ = 0.7 Gy, p = 0.042),和V50% (Δ = 20.4%, p 5%, D10%, D90%,所有30例患者与两种基准模式相比。然而,与临床和标准的SFRT计划相比,该模式显示PVDR降低,但仍达到bbb3.0的比率。与临床SFRT方案相比,所有不同孔径模式均显示关键器官的Dmax降低。此外,与临床SFRT和标准晶格图相比,11种差异孔尺寸模式中有9种显示V75%/V50%和V15Gy的增加。结论:所有不同孔径的SFRT重新规划均为临床可接受的,C = 3 cm, S = 2 cm, P = 1.5 cm为选择的肿瘤提供了最佳设置。差异晶格模式增强了对大体积肿瘤的消融剂量,同时限制了对邻近关键器官的最大消融剂量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.60
自引率
19.00%
发文量
331
审稿时长
3 months
期刊介绍: Journal of Applied Clinical Medical Physics is an international Open Access publication dedicated to clinical medical physics. JACMP welcomes original contributions dealing with all aspects of medical physics from scientists working in the clinical medical physics around the world. JACMP accepts only online submission. JACMP will publish: -Original Contributions: Peer-reviewed, investigations that represent new and significant contributions to the field. Recommended word count: up to 7500. -Review Articles: Reviews of major areas or sub-areas in the field of clinical medical physics. These articles may be of any length and are peer reviewed. -Technical Notes: These should be no longer than 3000 words, including key references. -Letters to the Editor: Comments on papers published in JACMP or on any other matters of interest to clinical medical physics. These should not be more than 1250 (including the literature) and their publication is only based on the decision of the editor, who occasionally asks experts on the merit of the contents. -Book Reviews: The editorial office solicits Book Reviews. -Announcements of Forthcoming Meetings: The Editor may provide notice of forthcoming meetings, course offerings, and other events relevant to clinical medical physics. -Parallel Opposed Editorial: We welcome topics relevant to clinical practice and medical physics profession. The contents can be controversial debate or opposed aspects of an issue. One author argues for the position and the other against. Each side of the debate contains an opening statement up to 800 words, followed by a rebuttal up to 500 words. Readers interested in participating in this series should contact the moderator with a proposed title and a short description of the topic
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