Case Report: IgG4-RD-related ophthalmopathy combined with monoclonal gammopathy of undetermined significance.

IF 5.7 2区医学 Q1 IMMUNOLOGY

Frontiers in Immunology Pub Date : 2025-05-12 eCollection Date: 2025-01-01 DOI:10.3389/fimmu.2025.1565388

Shanshan Liang, Wei Xu, Peiying Zhong, Chuanmin Tao, Li Zhang, Chengyao Jia

引用次数: 0

Abstract

IgG4-related disease (IgG4-RD), an immune-mediated fibroinflammatory disorder, has few reports in combination with monoclonal gammopathy of undetermined significance (MGUS). Herein, we present a case of a 69-year-old woman with manifestations of left orbital occupation and visual acuity decline. Ancillary tests indicated persistent positivity of IgG4 antibody, and IgG4-RD-related ophthalmopathy was diagnosed based on the criteria. Concurrently, serum protein electrophoresis revealed an M protein level of 12.23 g/L. Immunofixation electrophoresis suggested a positive IgG λ-type M protein, and MGUS was diagnosed in conjunction with bone marrow smear and flow cytometry.

查看原文本刊更多论文

病例报告：igg4 - rd相关眼病合并意义不明的单克隆伽玛病。

igg4相关疾病（IgG4-RD）是一种免疫介导的纤维炎性疾病，很少有与意义不明的单克隆γ病（MGUS）合并的报道。在此，我们报告一位69岁的女性，表现为左眼眶占位及视力下降。辅助检查显示IgG4抗体持续阳性，根据标准诊断为IgG4- rd相关性眼病。同时，血清蛋白电泳显示M蛋白水平为12.23 g/L。免疫固定电泳显示IgG λ型M蛋白阳性，结合骨髓涂片和流式细胞术诊断为MGUS。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Frontiers in Immunology IMMUNOLOGY-

CiteScore

9.80

自引率

11.00%

发文量

7153

审稿时长

14 weeks

期刊介绍： Frontiers in Immunology is a leading journal in its field, publishing rigorously peer-reviewed research across basic, translational and clinical immunology. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. Frontiers in Immunology is the official Journal of the International Union of Immunological Societies (IUIS). Encompassing the entire field of Immunology, this journal welcomes papers that investigate basic mechanisms of immune system development and function, with a particular emphasis given to the description of the clinical and immunological phenotype of human immune disorders, and on the definition of their molecular basis.