Abdullah Albahar, Ibrahim Torktaz, Massoud Houshmand
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引用次数: 0
Abstract
Background: Rheumatoid arthritis (RA) is a chronic inflammatory disease, presenting with joint inflammation and its progressive destruction, affecting a range of about 0.24-1% of the population in different parts of the world. It is one of the major disabling conditions among middle-aged and older women. In this study, the association between five single nucleotide polymorphisms (SNPs) of the CTLA4 gene and RA was investigated. Materials and Methods: The study group included 200 patients with RA and 184 healthy individuals from the Iranian population as a control group. Results: After PCR and genotyping, 4 of the 5 SNPs studied showed a significant association with RA. Also, an association between specific haplotypes with RA was determined. Conclusion: Based on the results, it can be said that some SNPs of the CTLA4 gene may serve as genetic markers for predicting RA susceptibility or progression and using personalized treatment, lead to improved outcomes among patients with RA.
期刊介绍：
Genetic Testing and Molecular Biomarkers is the leading peer-reviewed journal covering all aspects of human genetic testing including molecular biomarkers. The Journal provides a forum for the development of new technology; the application of testing to decision making in an increasingly varied set of clinical situations; ethical, legal, social, and economic aspects of genetic testing; and issues concerning effective genetic counseling. This is the definitive resource for researchers, clinicians, and scientists who develop, perform, and interpret genetic tests and their results.
Genetic Testing and Molecular Biomarkers coverage includes:
-Diagnosis across the life span-
Risk assessment-
Carrier detection in individuals, couples, and populations-
Novel methods and new instrumentation for genetic testing-
Results of molecular, biochemical, and cytogenetic testing-
Genetic counseling
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