A Systematic Review of the Neurological Benefits Associated With the Use of Targeted Hypothermia Temperature Management Versus Targeted Normothermia in Out-of-Hospital Cardiac Arrest Patients.

Abstract

Cardiac arrest, a condition in which the heart ceases to function and oxygen delivery to the brain and other vital organs is interrupted, affects 700 000 Americans annually. One of the most devastating consequences of cardiac arrest is the lack of oxygen delivery to the brain, resulting in anoxic brain injury and severe neurological dysfunction. The pivotal trial published in 2002 by Dr. Stephen Bernard and his team, touted the positive benefits of therapeutic temperature management on the neurological recovery of post-cardiac arrest patients and changed the way the scientific and medical communities viewed the use of hypothermia. Since then, research has seemingly confirmed the apparent benefits of hypothermia on neurological recovery but the question remains as to what temperature patients should be cooled to, and more recently, if patients should actively be cooled at all or if the medical team should strive to maintain normothermia. A thorough literature review identified 6 studies comparing the neurological benefits of targeted temperature management and targeted normothermia, and concluded that a change in clinical practice cannot be made based on the current literature.