Yuesu Chen, Cassian Desmons, Martin Cattoen and Jean-Christophe M. Monbaliu
{"title":"Open-source fraction collector for flash column chromatography and continuous flow reactions†","authors":"Yuesu Chen, Cassian Desmons, Martin Cattoen and Jean-Christophe M. Monbaliu","doi":"10.1039/D5RE00070J","DOIUrl":null,"url":null,"abstract":"<p >The design and construction of an open-source fraction collector and its applications in flash column chromatography are described. With the collection vials arranged in a circular array, the outlet of the flash column is guided by an arm to stay above each vial over a defined interval of time, liberating the chemists from the manual labor of swapping vials in high frequency. The assembly is constructed with flow reactor components (plunger pump, tubing, and valves) and optional 3D printed parts (vial holders and arm). The applicability of such a device is demonstrated through relevant examples from the daily work of a chemist, including the purification of crude products, the separation of a reaction mixture, and the fractional collection of effluents from continuous flow reactors.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 6","pages":" 1408-1416"},"PeriodicalIF":3.4000,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Reaction Chemistry & Engineering","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/re/d5re00070j","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The design and construction of an open-source fraction collector and its applications in flash column chromatography are described. With the collection vials arranged in a circular array, the outlet of the flash column is guided by an arm to stay above each vial over a defined interval of time, liberating the chemists from the manual labor of swapping vials in high frequency. The assembly is constructed with flow reactor components (plunger pump, tubing, and valves) and optional 3D printed parts (vial holders and arm). The applicability of such a device is demonstrated through relevant examples from the daily work of a chemist, including the purification of crude products, the separation of a reaction mixture, and the fractional collection of effluents from continuous flow reactors.
期刊介绍：
Reaction Chemistry & Engineering is a new journal reporting cutting edge research into all aspects of making molecules for the benefit of fundamental research, applied processes and wider society.
From fundamental, molecular-level chemistry to large scale chemical production, Reaction Chemistry & Engineering brings together communities of chemists and chemical engineers working to ensure the crucial role of reaction chemistry in today’s world.
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