Unveiling the medicinal diversity of benzoic acid containing molecules: Insights on druggable targets for type 2 diabetes mellitus

IF 3.3 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Bioorganic & Medicinal Chemistry Pub Date : 2025-05-22 DOI:10.1016/j.bmc.2025.118245

Kajal Rani , Preety Kumari , Anita Kumari , Debarshi Mondal , Priya Bisht , Rupali Kohal , Vivek Asati , Ghanshyam Das Gupta , Sant Kumar Verma

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引用次数: 0

Abstract

Benzoic acid, a versatile aromatic carboxylic acid, has gained attention as a promising scaffold for developing therapeutic agents targeting diabetes mellitus, a chronic metabolic disorder characterized by persistent hyperglycemia and associated complications. Structural analysis elucidated how modifications to the benzoic acid structure enhance pharmacological efficacy by influencing glucose metabolism, insulin sensitivity, and oxidative stress pathways. Notably, benzoic acid derivatives exhibit inhibitory effects on key enzymes such as protein tyrosine phosphatase 1B (PTP1B), dipeptidyl peptidase-4 (DPP-4), α-glucosidase, peroxisome proliferator-activated receptor gamma (PPAR-γ), and aldose reductase, which are implicated in diabetes pathophysiology. Molecular docking simulations further reveal the molecular interactions underlying these effects, supporting the potential of these derivatives in multi-targeted therapies. This review integrates findings from SAR studies of benzoic acid synthesized over two decades, showcasing significant advancements in the design and development of benzoic acid derivatives as promising candidates for the effective management of diabetes and its associated complications.

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揭示含苯甲酸分子的药用多样性：对2型糖尿病药物靶点的见解

苯甲酸是一种多功能芳香羧酸，作为一种有前景的支架，用于开发针对糖尿病的治疗药物，糖尿病是一种以持续高血糖和相关并发症为特征的慢性代谢疾病。结构分析阐明了苯甲酸结构的修饰如何通过影响葡萄糖代谢、胰岛素敏感性和氧化应激途径来增强药理作用。值得注意的是，苯甲酸衍生物对蛋白酪氨酸磷酸酶1B （PTP1B）、二肽基肽酶4 （DPP-4）、α-葡萄糖苷酶、过氧化物酶体增殖物激活受体γ (PPAR-γ)和醛糖还原酶等关键酶具有抑制作用，这些酶与糖尿病病理生理有关。分子对接模拟进一步揭示了这些作用背后的分子相互作用，支持了这些衍生物在多靶向治疗中的潜力。这篇综述整合了过去二十年来合成苯甲酸的SAR研究结果，展示了苯甲酸衍生物的设计和开发取得的重大进展，苯甲酸衍生物有望成为有效治疗糖尿病及其相关并发症的候选药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Bioorganic & Medicinal Chemistry 医学-生化与分子生物学

CiteScore

6.80

自引率

2.90%

发文量

413

审稿时长

17 days

期刊介绍： Bioorganic & Medicinal Chemistry provides an international forum for the publication of full original research papers and critical reviews on molecular interactions in key biological targets such as receptors, channels, enzymes, nucleotides, lipids and saccharides. The aim of the journal is to promote a better understanding at the molecular level of life processes, and living organisms, as well as the interaction of these with chemical agents. A special feature will be that colour illustrations will be reproduced at no charge to the author, provided that the Editor agrees that colour is essential to the information content of the illustration in question.