Clinical characteristics associated with multiple sclerosis fatigue severity

IF 2.9 3区医学 Q2 CLINICAL NEUROLOGY

Multiple sclerosis and related disorders Pub Date : 2025-05-22 DOI:10.1016/j.msard.2025.106528

Alexandra Balshi , John P Dempsey , Nova Manning , Manuela Kriemler , Sachin Kumbar , Grace Leuenberger , Larry Padilla , Ursela Baber , Jacob A Sloane

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引用次数: 0

Abstract

Background

While clinical factors such as higher Expanded Disability Status Scale (EDSS) score, progressive disease subtype, older age, polysymptomatic onset, and depression have been shown to predict fatigue severity in people with multiple sclerosis (PwMS), their influences have not been evaluated simultaneously while controlling for broader MS severity risk factors and potential confounders.

Objective

To concurrently assess which previously established MS fatigue risk factors affect fatigue severity after adjusting for MS severity, obstructive sleep apnea (OSA), and stimulant use, and to validate these findings using a second fatigue scale.

Methods

We used multivariable linear regression to determine relationships between MS clinical data and MS-related fatigue as measured by the Modified Fatigue Impact Scale (MFIS) and the Fatigue Severity Scale (FSS), controlling for OSA and stimulant use.

Results

Polysymptomatic MS onset (MFIS β = 9.22, p = 0.027; FSS β = 5.90, p = 0.032), depression (MFIS β = 22.01, p < 0.001; FSS β = 13.51, p = 0.003), and higher Expanded Disability Status Scale (EDSS) scores (MFIS β = 2.32, p = 0.028) were associated with more severe fatigue in PwMS.

Conclusion

Polysymptomatic MS onset, comorbid depression, and higher EDSS score remain independently associated with MS fatigue severity even when evaluated together adjusting for relevant controls. PwMS with these characteristics, especially those with all three, should be screened for fatigue and offered symptomatic treatment.

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与多发性硬化症疲劳程度相关的临床特征

虽然临床因素，如较高的扩展残疾状态量表（EDSS）评分、进行性疾病亚型、年龄较大、多症状发作和抑郁已被证明可以预测多发性硬化症（PwMS）患者的疲劳严重程度，但在控制更广泛的MS严重程度危险因素和潜在混杂因素的同时，尚未对其影响进行评估。目的评估在调整多发性硬化症严重程度、阻塞性睡眠呼吸暂停（OSA）和兴奋剂使用后，哪些先前确定的多发性硬化症疲劳危险因素会影响疲劳严重程度，并使用第二种疲劳量表验证这些发现。方法采用修正疲劳影响量表（MFIS）和疲劳严重程度量表（FSS），控制OSA和兴奋剂使用，采用多变量线性回归分析MS临床数据与MS相关疲劳之间的关系。结果多发性硬化发病(MFIS β = 9.22, p = 0.027；FSS β = 5.90, p = 0.032)，抑郁(MFIS β = 22.01, p <；0.001;FSS β = 13.51, p = 0.003)，更高的扩展残疾状态量表（EDSS）评分（MFIS β = 2.32, p = 0.028）与PwMS患者更严重的疲劳相关。结论：多发性硬化症发病、合并症抑郁和较高的EDSS评分与多发性硬化症疲劳严重程度仍然独立相关，即使在调整相关对照的同时进行评估。具有这些特征的PwMS，特别是具有所有三个特征的PwMS，应筛查疲劳并提供对症治疗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Multiple sclerosis and related disorders CLINICAL NEUROLOGY-

CiteScore

5.80

自引率

20.00%

发文量

814

审稿时长

66 days

期刊介绍： Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.