Relationship Between Leptin and Heart Failure: A Meta-Analysis.

IF 3.1 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Global Heart Pub Date : 2025-05-23 eCollection Date: 2025-01-01 DOI:10.5334/gh.1434

Xin Sun, Caihong Xin, Jiayi Yao, Hongli Wang

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引用次数: 0

Abstract

Background: Heart failure (HF) is a diverse and potentially fatal condition affecting more than 60 million people worldwide. Previous studies have identified a close relationship between leptin levels and HF, and that leptin levels in patients with HF are higher than those in healthy individuals. However, some studies have reported inconsistent results. Therefore, the association between leptin levels and HF remains controversial.

Methods: A literature search was conducted on the Web of Science, Wiley Online Library, Embase, and PubMed databases. The title or abstract search term 'leptin' was used in combination with 'heart failure' and 'HF'. Meta-analysis results were reported as standardized mean differences (SMD) with corresponding 95% confidence intervals (CI).

Results: Eighteen studies comprising 1149 patients with HF and 622 healthy controls were included in the meta-analysis. Leptin levels in patients with HF were significantly higher than those in healthy individuals (SMD, 0.54; 95% CI [0.15, 0.93]).

Conclusions: To our knowledge, this systematic review is the first to evaluate the relationship between leptin and HF. Determining the role of leptin in HF will significantly contribute to its diagnosis and treatment.

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瘦素与心力衰竭的关系：一项meta分析。

背景：心力衰竭（HF）是一种多种多样且可能致命的疾病，影响着全球6000多万人。先前的研究已经确定了瘦素水平与HF之间的密切关系，并且HF患者的瘦素水平高于健康人。然而，一些研究报告了不一致的结果。因此，瘦素水平与HF之间的关系仍然存在争议。方法：在Web of Science、Wiley Online Library、Embase和PubMed数据库中进行文献检索。标题或抽象搜索词“瘦素”与“心力衰竭”和“心力衰竭”结合使用。meta分析结果以标准化平均差异（SMD）报告，并具有相应的95%置信区间（CI）。结果：18项研究包括1149例心衰患者和622例健康对照纳入meta分析。HF患者瘦素水平显著高于健康人(SMD, 0.54；95% ci[0.15, 0.93])。结论：据我们所知，本系统综述首次评价了瘦素与心衰之间的关系。确定瘦素在心衰中的作用将对其诊断和治疗有重要意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Global Heart Medicine-Cardiology and Cardiovascular Medicine

CiteScore

5.70

自引率

5.40%

发文量

审稿时长

5 weeks

期刊介绍： Global Heart offers a forum for dialogue and education on research, developments, trends, solutions and public health programs related to the prevention and control of cardiovascular diseases (CVDs) worldwide, with a special focus on low- and middle-income countries (LMICs). Manuscripts should address not only the extent or epidemiology of the problem, but also describe interventions to effectively control and prevent CVDs and the underlying factors. The emphasis should be on approaches applicable in settings with limited resources. Economic evaluations of successful interventions are particularly welcome. We will also consider negative findings if important. While reports of hospital or clinic-based treatments are not excluded, particularly if they have broad implications for cost-effective disease control or prevention, we give priority to papers addressing community-based activities. We encourage submissions on cardiovascular surveillance and health policies, professional education, ethical issues and technological innovations related to prevention. Global Heart is particularly interested in publishing data from updated national or regional demographic health surveys, World Health Organization or Global Burden of Disease data, large clinical disease databases or registries. Systematic reviews or meta-analyses on globally relevant topics are welcome. We will also consider clinical research that has special relevance to LMICs, e.g. using validated instruments to assess health-related quality-of-life in patients from LMICs, innovative diagnostic-therapeutic applications, real-world effectiveness clinical trials, research methods (innovative methodologic papers, with emphasis on low-cost research methods or novel application of methods in low resource settings), and papers pertaining to cardiovascular health promotion and policy (quantitative evaluation of health programs.