Inflammatory status of periprostatic adipose tissue from men with prostate cancer: Ethno-geographic variations and association with lipid composition.

IF 2.3 3区医学 Q3 ONCOLOGY

Urologic Oncology-seminars and Original Investigations Pub Date : 2025-05-24 DOI:10.1016/j.urolonc.2025.04.001

Michel Samson, Michèle Pinault, Franck Bruyère, Pascal Blanchet, Souhil Lebdai, Georges Fournier, Jerome Rigaud, Romain Mathieu, Gaëlle Fromont

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Abstract

Background: Since prostate cancer (PCa) risk is associated with ethnicity, it is crucial to investigate ethno-geographic variations in PCa studies. Periprostatic adipose tissue (PPAT) has been involved in cancer aggressiveness through the release of lipids and inflammatory mediators, and we previously reported a different lipid composition of PPAT according to the ethno-geographic origin. We aimed to analyze the expression of a panel of adipokines in PPAT from African-Caribbean and Caucasian patients, in correlation with features of PCa aggressiveness and lipid composition.

Methods: Adipokines expression was analyzed by RTqPCR in PPAT from 110 Caucasians and 50 African-Caribbeans patients, in parallel with the characterization of fatty acids and cholesterol content.

Results: The most expressed cytokines were IL10, leptin and IL8. The expression of most adipokines was higher in PPAT from Caucasians compared to African-Caribbean patients. IL6 was associated with features of PCa aggressiveness in Caucasians, with a difference close to significance. Most cytokines were associated with the lipid composition of PPAT, mainly with arachidonic acid and free cholesterol content.

Conclusions: The differential cytokines expression in PPAT from African-Caribbean patients compared to Caucasians probably reflects a different inflammatory status. The close relationship between adipokines expression and lipid composition highlights the importance of diet and lipid metabolism in adipose tissue inflammation.

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前列腺癌患者前列腺周围脂肪组织的炎症状态：民族地理差异及其与脂质组成的关系

背景：由于前列腺癌（PCa）的风险与种族有关，因此研究前列腺癌研究中的种族地理差异是至关重要的。前列腺周围脂肪组织（PPAT）通过释放脂质和炎症介质参与癌症侵袭性，我们之前报道过PPAT根据种族地理起源的不同脂质组成。我们的目的是分析一组脂肪因子在非洲-加勒比和高加索患者PPAT中的表达，与PCa侵袭性和脂质组成的特征相关。方法：采用RTqPCR方法分析110例白种人和50例非洲-加勒比人PPAT中脂肪因子的表达，并对脂肪酸和胆固醇含量进行表征。结果：白细胞介素（IL10）、瘦素（leptin）和白细胞介素（IL8）表达最多。与非洲-加勒比患者相比，高加索人的PPAT中大多数脂肪因子的表达更高。il - 6与白种人前列腺癌侵袭性特征相关，差异接近显著。大多数细胞因子与PPAT的脂质组成有关，主要与花生四烯酸和游离胆固醇含量有关。结论：与高加索人相比，非洲-加勒比人PPAT患者细胞因子表达的差异可能反映了不同的炎症状态。脂肪因子表达与脂质组成之间的密切关系凸显了饮食和脂质代谢在脂肪组织炎症中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Urologic Oncology-seminars and Original Investigations 医学-泌尿学与肾脏学

CiteScore

4.80

自引率

3.70%

发文量

297

审稿时长

7.6 weeks

期刊介绍： Urologic Oncology: Seminars and Original Investigations is the official journal of the Society of Urologic Oncology. The journal publishes practical, timely, and relevant clinical and basic science research articles which address any aspect of urologic oncology. Each issue comprises original research, news and topics, survey articles providing short commentaries on other important articles in the urologic oncology literature, and reviews including an in-depth Seminar examining a specific clinical dilemma. The journal periodically publishes supplement issues devoted to areas of current interest to the urologic oncology community. Articles published are of interest to researchers and the clinicians involved in the practice of urologic oncology including urologists, oncologists, and radiologists.