Elevated MPV: A Key Indicator of Acute Anterior Circulation Stroke Prognosis in Mechanical Thrombectomy.

IF 2.8 3区医学 Q1 Pharmacology, Toxicology and Pharmaceutics

Therapeutics and Clinical Risk Management Pub Date : 2025-05-19 eCollection Date: 2025-01-01 DOI:10.2147/TCRM.S522253

Shi-Yuan Tian, Min-Jie Yu, Kefu Mei, Bing Xu, Lian-Chen Xiao, Hong-Bin Wen, Fu-Rong Shang

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Abstract

Objective: The aim of this study is to investigate the relationship between admission platelet indices and 90-day clinical outcomes in patients with acute ischemic stroke (AIS) undergoing mechanical thrombectomy (MT).

Methods: A retrospective analysis was conducted on 247 AIS patients with anterior circulation large vessel occlusion (LVO) treated with MT between July 2021 and April 2024. Platelet indices (PIs) were measured at admission. Participants were stratified into two groups based on 90-day modified Rankin Scale (mRS) outcomes. Multivariate regression analysis and receiver operating characteristic (ROC) curves were employed to evaluate relationships between admission platelet indices, clinical parameters, and functional outcomes.

Results: Among 247 enrolled patients, those with unfavorable outcomes (mRS 3-6) exhibited significantly higher platelet distribution width (PDW) and Mean Platelet Volume (MPV) levels compared to the favorable outcome group (mRS 0-2). Elevated MPV remained an independent predictor of unfavorable outcomes after multivariate adjustment (OR=2.747, 95% CI: 1.791-4.216, P<0.001). ROC analysis identified a MPV threshold >10.75 fL for predicting unfavorable prognosis, demonstrating 55.4% sensitivity and 81.2% specificity.

Conclusion: PDW is associated with unfavorable 90-day outcomes in patients with acute anterior circulation LVO following MT, while elevated MPV may serve as a prognostic indicator for unfavorable functional outcomes in patients with acute anterior circulation LVO following MT.

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机械取栓术中MPV升高：急性前循环卒中预后的关键指标。

目的：探讨急性缺血性脑卒中（AIS）机械取栓（MT）患者入院时血小板指数与90天临床结局的关系。方法：回顾性分析2021年7月至2024年4月接受MT治疗的247例AIS前循环大血管闭塞（LVO）患者。入院时测定血小板指数（pi）。根据90天的改良Rankin量表（mRS）结果将参与者分为两组。采用多变量回归分析和受试者工作特征（ROC）曲线评价入院血小板指标、临床参数和功能结局之间的关系。结果：在247例入组患者中，不良结局组（mRS 3-6）的血小板分布宽度（PDW）和平均血小板体积（MPV）水平明显高于良好结局组（mRS 0-2）。多因素调整后，MPV升高仍然是预测不良预后的独立预测因子（OR=2.747, 95% CI: 1.791-4.216, P10.75 fL），敏感性为55.4%，特异性为81.2%。结论：PDW与MT后急性前循环LVO患者90天的不良预后相关，而MPV升高可作为MT后急性前循环LVO患者不良功能预后的预后指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutics and Clinical Risk Management HEALTH CARE SCIENCES & SERVICES-

CiteScore

5.30

自引率

3.60%

发文量

139

审稿时长

16 weeks

期刊介绍： Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas. The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature. As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication. The journal does not accept study protocols, animal-based or cell line-based studies.